Little is known about the adverse effects of substances, such as pesticides and metals, on the development of mild cognitive dysfunction (MCD). Cross-sectional and prospective data from the Maastricht Aging Study were used to find out the potential neurotoxicity of particular substances. Exposure to pesticides, for example by arable farmers and gardeners, was associated with increased risks of ...

This review, covering a timespan of almost a century, attempts to answer five pressing questions: (1) Are intraspinal steroid therapies eVective for back pain or radicular syndromes? (2) Do epidural injections remain confined to the epidural space? (3) Are presently prescribed steroid formulations neurotoxic? (4) What are the risks of epidural steroid injection? (5) What information should be g...

The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a "wonder" drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the...

Affiliation: REQUIMTE, Toxicology Dept., Faculty of Pharmacy, Univ. Porto, Porto, Portugal (J.P.C., F.R., M.L.B., F.C.) Neurology Dept., Charité Hospital, Humboldt Univ., Berlin, Germany (A.M.) REQUIMTE/CQFB, Chemistry Dept., Faculty of Science and Technology, Univ. Nova de Lisboa, Monte de Caparica, Portugal (A.R.A., P.S.B., L.M.F., A.M.L.) JPET Fast Forward. Published on September 23, 2005 as...

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T951115 Page 2 Chromosome effects: No data gap, no adverse effect2 DNA damage: No data gap, no adverse effect Neurotoxicity: Not required at this time

To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/1 microliter) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method fo...

Toxaphene production, in quantities similar to those of polychlorinated biphenyls, has resulted in high toxaphene levels in fish from the Great Lakes and in Arctic marine mammals (up to 10 and 16 microg g-1 lipid). Because of the large variabiliity in total toxaphene data, few reliable conclusions can be drawn about trends or geographic differences in toxaphene concentrations. New developments ...

Chromosome effects: No data gap, no adverse effect DNA damage: No data gap, possible adverse effect Neurotoxicity: Not required at this time

Explanation.................................................................................................... 203 Evaluation for acceptable daily intake .......................................................... 204 Biochemical aspects ................................................................................ 204 Absorption, distribution and excretion ......................................