In order to investigate the involvement of cyclooxygenase (COX)-2 in cell growth and invasion of oral cancer, a human epidermoid carcinoma cell line KB minimally expressing COX-2 protein was transfected with COX-2 cDNA and these activities were compared with mock-transfected KB in vitro and in vivo. KB/COX-2 clones showed a similar growth rate in vitro compared to KB/neo clones, but demonstrate...

The transformation to Network Enabled Operations (NEO) is based on a vision of intensive military cooperation and information sharing by making use of network technologies. Underlying this vision are moral assumptions on how people will behave when operating in a network. The current status of NEO research leaves out the ethical dimension of working in a highly technologically mediated environm...

The methodology for a vibrational analysis within the nuclear–electronic orbital ~NEO! framework is presented. In the NEO approach, specified nuclei are treated quantum mechanically on the same level as the electrons, and mixed nuclear–electronic wave functions are calculated variationally with molecular orbital methods. Both electronic and nuclear molecular orbitals are expressed as linear com...

Among the geometrical isomers of vitamin A and retinene, the neo-b isomer occupies a special position. As the precursor of rhodopsin and iodopsin, it plays a central r81e in rod and cone vision (1, 2). It is stored almost exclusively in the eyes of certain Crustacea (3) and is equally distinctive chemically. The four unhindered geometrical isomers of vitamin A have been identified (4, 5); neo-b...

I'HIS paper is based on1 experience-often bitter experience-and makes no pretence at summarizing the literature, which makes the whole problem sound far too easy. As we all know, textbook cases occur only in textbooks. Nor shall I quote the incidence of various conditions per one thousand live births. To know that something happens once in every two thousand babies is no help in deciding whethe...

Darwinian medicine is the treatment of disease based on evolution. The underlying assumption of Darwinian medicine is that traits are coded by genes, which are often assumed to be sequences of DNA nucleotides. The quantitative genetic ramification of this perspective is that traits, including disease susceptibility, are either caused by genes or by the environment, with genotype-by-environment ...

The aim of this study was to investigate the behavior of the protonated paralytic shellfish poisons saxitoxin (STX) and neosaxitoxin (NEO) in the gas-phase after ion activation using different tandem mass spectrometry techniques. STX and NEO belong to a group of neurotoxins produced by several strains of marine dinoflagellates. Their chemical structures are based on a tetrahydropurine skeleton ...

The aim of this study was to analyse the psychometric properties of the Spanish NEO Five Factor Inventory-Revised (NEO-FFI-R) using Rasch analyses, in order to test its rating scale functioning, the reliability of scores, internal structure, and differential item functioning (DIF) by gender in a psychiatric sample. The NEO-FFI-R responses of 433 Spanish adults (154 males) with an anxiety disord...

Microsatellites known as “CubeSats” have recently been developed to enable comparatively inexpensive and timely access to space for small payloads. As a new standard for small satellites, the CubeSat has shown great promise for space applications such as earth observation, planetary science and space physics mission. In this paper a “CubeSail” mission – a CubeSat deployed with a solar sail –for...