Sarcoidosis is a multisystem granulomatous disease characterized by hilar lymphadenopathy, involvement of internal organs, and diverse skin lesions. Systemic sclerosis is an autoimmune disease characterized by skin hardening and different internal organ fibrosis, including vascular abnormality. Immune response associated with Th-2 has been shown in the early and active stage of the disease. In ...

scleroderma is a multisystem autoimmune connective tissue disease, cliaracterized by hardening of the skin. hv had 25 patients in the iranian pediatric unit of rheumatology over 10 years. there was female predominance if.m = 4/1, 80% female, 20% male). the age of onest was from 6 months to 16 years, the mean age being 10 years. the symptoms and signs were: nonpitting edema in 16%, liard skin in...

Behcet’s disease is a multisystem inflammatory disorder of unknown origin, characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis, central nervous system and vascular disease. There is no pathognomanic laboratory test, but there are clinical criteria to assist in establishing the diagnosis. There are only a few study about the laryngeal manifestation of...

Immunoglobulin (Ig) G4-related sclerosing disease is a newly defined clinicopathological entity characterized by lymphoplasmacytic infiltration of IgG4-positive plasma cells and varying degrees of fibrosis within affected tissues. Patients usually exhibit multisystem involvement and often respond well to steroid and immunosuppressive therapy. This report presents a case of IgG4-related sclerosi...

Coronavirus disease 2019 (COVID-19) is an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with substantial cardiovascular implications. Although infection SARS-CoV-2 usually mild in children, some children later develop a inflammatory that can have manifestations similar to toxic shock or Kawasaki disease. This has been defined US Centers for Disease Contro...

BACKGROUND Eosinophilia has not been reported as a manifestation of a mitochondrial disorder (MID). Here, we report a patient with clinical features suggesting a MID and permanent eosinophilia, multisystem disease, and progressive hyper-creatine-kinase (CK)-emia for at least 10 years. MATERIALS AND METHODS Methods applied included a clinical exam, blood chemical investigations, electrophysiol...

BACKGROUND Charles Darwin (CD), "father of modern biology," suffered from multisystem illness from early adulthood. The most disabling manifestation was cyclic vomiting syndrome (CVS). This study aims at finding the possible cause of CVS in CD. METHODS A literature search using the PubMed database was carried out, and CD's complaints, as reported in his personal writings and those of his rela...