Chitosan-based films are promising for consideration as packaging materials. In this study, we modified the chitosan by phenolic acid addition, such ferulic acid, caffeic tannic and gallic acid. The mechanical thermal properties were studied, water vapor permeability rate was determined. Moreover, antioxidant activity film color considered. results showed that acids effective cross-linkers chit...

BACKGROUND Absorption of antigens onto chitosan microparticles via electrostatic interaction is a common and relatively mild process suitable for mucosal vaccine. In order to increase the stability of antigens and prevent an immediate desorption of antigens from chitosan carriers in gastrointestinal tract, coating onto BSA loaded chitosan microparticles with sodium alginate was performed by lay...

A novel modified chitosan carrying covalently linked imidazole groups (average molecular weight 700,000, degree of substitution 0.28, degree of acetylation 0.08) was used to stimulate bone formation in an animal model. Lesions (7 mm diameter) were surgically made in the femoral condyle of sheep and treated with the modified chitosan. Within 40 d after surgery, the neoformed tissue occluded the ...

Secondary caries are a worldwide public and socioeconomic problem. The placement of restorations can lead to the development of environmental conditions favorable to microbial colonization, especially on the tooth/restoration interface, which is a predisposing factor for secondary caries. The aim of this study was to evaluate microbial retention on conventional (Chelon-Fil and Vidrion R) and re...

Tissue repair and regeneration is an interdisciplinary field focusing on development of biological and bioactive substitutes. Chitosan is a natural polysaccharide exhibiting excellent biocompatibility, biodegradability, affinity to biomolecules, and wound-healing activity. It can also be easily modified via chemical and physical reactions to obtain derivatives of various structures, properties,...

Chitosan is a naturally occurring cationic polysaccharide and has attracted much attention in the past decade as an important ophthalmic biomaterial. We recently demonstrated that the genipin (GP) cross-linked chitosan is compatible with human retinal pigment epithelial cells. The present work aims to further investigate the in vivo biocompatibility of GP-treated chitosan (GP-chi group) by adop...

Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and ...

In this paper, ultrafine particles of crystalline hydroxyapatite were synthesized by hydrothermal treatment at 180C, and the surface of hydroxyapatite particles was modified by hexametaphosphate for the excellent dispersion properties of HA in the scaffolds. The phase separation was used to fabricate the scaffolds of polycaprolacton/chitosan and hydroxyapatite/polycaprolacton-chitosan. The effe...

BACKGROUND Restoring carious teeth is one of the major treatment needs of young children. Glass ionomer cement (GIC) systems had become the most important dental restorative and luting materials for use in preschoolers, children and teenagers. Several attempts in developing GIC with antibacterial effects by addition of bactericides, such as chlorhexidine, have been reported. AIM AIM of the st...