A 47‐year‐old woman with mixed connective tissue disease was treated abatacept. After 2 months, a 3‐cm depression atrophied surface observed on her back, which had histopathological consistent the symptoms of localized scleroderma. Although some cases paradoxical reaction or cutaneous adverse event have been reported from abatacept, no scleroderma has reported, suggesting this to be unique case.

Temporary remission of scleroderma during the successful treatment of an associated malignant lymphoma by chemotherapy is reported in a patient with systemic sclerosis and mixed connective tissue disease. There is a well established relation between malignant disease and polymyositis/dermatomyositis but no overall association with systemic sclerosis or mixed connective tissue disease. Reports o...

CC: calcinosis cutis DLE: discoid lupus erythematosus SLE: systemic lupus erythematosus INTRODUCTION Calcinosis cutis (CC) is a rare disorder known to occur commonly in association with underlying autoimmune connective tissue diseases. CC primarily occurs in patients with dermatomyositis, systemic scleroderma, and mixed connective tissue disease. It is only rarely associated with systemic lupus...

BACKGROUND The presence of nail-fold capillary abnormalities may be useful in diagnosing several connective tissue disorders, including scleroderma, dermatomyositis, and mixed connective tissue disease, and in differentiating primary Raynaud phenomenon from Raynaud phenomenon due to scleroderma and mixed connective tissue disease. Capillaroscopy, however, usually requires special equipment and ...

Mixed connective tissue disease is an increasingly recognized entity in which renal disease is thought to be unusual and associated hypocomplementaemia even more uncommon. A patient is described who had both these features and who also illustrates many of the characteristic features of this syndrome. The response to steroids of the systemic sclerosis component is well shown and an additional fe...

IZUMIYAMA, T., HIDA, W., ICHINOSE, M., INOUE, H., TAKISHIMA, T., OKAZAKI, T. and SHIRATO, K. Small Airway Involvement in Mixed Connective Tissue Disease. Tohoku J. Exp. Med., 1993, 170 (4), 273-283 We studied pulmonary functions in 17 female patients with mixed connective tissue disease (MCTD) to detect early pulmonary involvement in this disease; in 8 of the 17 patients followup studies were a...

We present a 28-year-old woman with mixed connective tissue disease (MCTD) complicated by a recalcitrant longstanding leg ulcer, which responded to complex therapy with local polydine, systemic ciprofloxacin, iloprost, enoxaparin and aspirin. Cyclophosphamide pulse therapy and corticosteroids controlled the systemic inflammation but failed to heal the leg ulcer. We considered a rationale of com...

Results VO2peak was significantly lower in patients with MCTD compared to the VO2peak of healthy subjects (z-score -1.9, p = 0.008). The strength of the proximal muscles (hip flexors, shoulder abductors, knee extensors) of the patients was significantly lower than the controls, whereas the strength of the distal muscles (dorsal flexors of the foot and grip strength) was rather similar. No clini...