Aim and Background: Sedation may alter memory learning. This study is designed to investigate the effects of short-acting sedative agents, propofol midazolam, on learning in mice. Materials Methods: Thirty male, adult Swiss-albino mice were randomly assigned into three groups as control, midazolam (n=10, for each). Experiments started 72 hours after intraperitoneal injections. Learning short te...

Most fearful and uncooperative children can be managed with behavioral management techniques. However, when behavioral management strategies fail, some form of pharmacologic sedation or anesthesia has to be utilized. Midazolam, one of the commonly used oral sedation agent in children has several characteristics such as safety of use, rapid onset and some degree of amnesia that makes it a desira...

With its high worldwide mortality and morbidity, cancer has gained increasing attention and novel anticancer drugs have become the focus for cancer research. Recently, studies have shown that most anesthetic agents can influence the activity of tumor cells. Midazolam is a γ-aminobutyric acid A (GABAA) receptor agonist, used widely for preoperative sedation and as an adjuvant during neuraxial bl...

Conscious Sedation is a technique in which the use of a drug produces a state of depression of central nervous system enabling treatment to be carried out, but during which verbal contact with the patients is maintained throughout the period of sedation. Various drugs have been used as sedative agents in pediatric dentistry to produce conscious sedation such a nitrous oxide, diazepam, midazolam...

Emotional changes can influence feeding behavior. Previous studies have shown that chronically stressed animals present increased ingestion of sweet food, an effect reversed by a single dose of diazepam administered before testing the animals. The aim of the present study was to evaluate the response of animals chronically treated with midazolam and/or submitted to repeated restraint stress upo...

BACKGROUND The minimum time interval between administration of oral midazolam and separation of children from their parents that ensures good anterograde amnesia has not been previously determined. This is of particular importance in a busy operating room setting where schedule delays secondary to midazolam administration may not be tolerated. METHODS Children (n = 113) undergoing general ane...

The aim of this study was to determine the bioavailability and absorption kinetics of midazolam given as an intranasal (i.n.) spray. In addition, plasma concentrations of the active metabolite, 1-hydroxymidazolam, were measured to give an indication of enteral absorption. An i.v. and i.n. midazolam dose were given in a crossover study to 14 adult surgical patients. Individual uptake profiles of...

BACKGROUND Although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. We performed the present study to compare the effect of paracetamol/midazolam with fentanyl/ midazolam. METHODS In a clinical trial, 96 patients aged 18 to 75 years old, who were c...

Midazolam was administered intravenously to 8 bitches in a randomised, placebo-controlled clinical trial before propofol induction of surgical anaesthesia. Anaesthesia was maintained with isoflurane-in-oxygen during surgical endoscopic examination of the uterus and ovariohysterectomy. Clenbuterol was administered at the start of surgery to improve uterine muscle relaxation, and to facilitate en...

A binding pocket for thyrotropin-releasing hormone (TRH) within the transmembrane helices of the TRH receptor type 1 (TRH-R1) has been identified based on experimental evidence and computer simulations. To determine the binding site for a competitive inverse agonist, midazolam, three of the four residues that directly contact TRH and other residues that restrain TRH-R1 in an inactive conformati...