Objective(s): Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL/6J mice fed a normal diet.Materials and Methods: Female C57BL/6J mice ora...

Background: The radioprotective effect of Grewia asiatica fruit (GAE) which contains anthocyanin type cyanidin 3- glucoside, vitamin C, A, minerals, carotenes and dietary fibers etc was studied. Materials and Methods: For study Swiss albino mice were divided into five groups-1. Control (vehicle treated) 2. GAE treated (700 mg / Kg. b.wt / day for fifteen days), 3. Irradiated (5 Gy), 4. G...

Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved the activation, proliferation, migration of HSCs. We investigated whether may induce hepatic The mice were randomly divided into 2 groups —the control group (chow diet-fed mice, n = 26) sodium (2% + chow diet, 38). Each diet was provided for 16 weeks. Mice adm...

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease (NAFLD). The effects of two strains Limosilactobacillus mucosae (L. mucosae) on NAFLD were investigated in this study. Four-week-old male C57BL/6J mice divided into four groups (n=8 per group, Control, Model, FZJTZ26M3, FGSYC17L3). FZJTZ26M3 reduced the mice's body weight, ...

endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...

5-Aminolevulinic acid (ALA) is the rate-limiting intermediate in heme biosynthesis vertebrate species; a reaction catalyzed by mitochondrial ALA synthase 1 (ALAS1) enzyme. Previously we reported that knockdown of ubiquitously expressed ALAS1 gene mice disrupts normal glucose metabolism, attenuates function and results prediabetic like phenotype when animals pass 20-weeks age (Saitoh et al., 201...

conclusions in conclusion, our observations indicated that pcdna3.1 (+)-hbv1.3c was superior to aav/hbv plasmid for establishment of persistent hbv infection by hi, in vivo, and this mouse model could be useful for studies of hepatitis virology and for the development of innovatory treatments for hbv infections. results in 60% of the mice injected with pcdna3.1 (+)-hbv1.3c, hbsag, hbeag, hbcag ...

background & aim: cutaneous infection caused by protozoa the genus leishmania are a major worldwide health problem, with high endemicity in developing countries including middle east, africa and latin america. in the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. experimental: in this study, the in vivo efficacy of artemisia...

Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes (A. europaea) is a medicinal plant widely used in traditional medicines to treat various diseases including hepatic pathogenesis. This study was conducted evaluate the protective effect of chemically characterized polyphenol-rich fraction from A. on carbon tetrachloride-induced liver injury mice. The chemical characterization ...