Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. There are controversy aspects about its teratogenicity. A teratogenic agent can alter morphology or subsequent function of the fetus. The aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Metronidazole usin...

Introduction: Depression is a common psychiatric disorder and about one in five people experience depression during their lifespan. Despite the anti-depressive effects of drug therapy, problems such as non-targeting and dose-resistant lead to more effective approaches. Transcranial Photobiomodulation (TPBM) or transcranial low-level laser (TLLL) therapy is a novel and neuropro...

Increased blood–brain barrier (BBB) permeability and extensive neuronal changes have been described earlier in both healthy pathological aging like apolipoprotein B-100 (APOB-100) amyloid precursor protein (APP)–presenilin-1 (PSEN1) transgenic mouse models. APOB-100 hypertriglyceridemic model is a useful tool to study the link between cerebrovascular pathology neurodegeneration, while APP–PSEN1...

Traumatic brain injury (TBI) is a clinical emergency with very high incidence, disability, and fatality rate. Minocycline, widely used semisynthetic second-generation tetracycline antibiotic, has anti-inflammatory bactericidal effects. However, minocycline not been explored as therapeutic drug in TBI if effective, the related molecular mechanism also unclear. In this study, we examined neuropro...

Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive. To further understand this, investigation was conducted on physical training’s effects behavior, balance, genomic stability in GBMA models. Forty-seven male C57BL/6J mice, 60 days old, were divided into GBM sham groups (n = 15, n 10, ...

BackgroundNeuroinflammation can occur during sepsis and is now regarded as the main mechanism underlying various related central nervous system (CNS) disorders. Another well-known factor causing neuroinflammation psychological stress. In current study, we examined effects of prior exposure to stress on sepsis-induced CNS symptoms.Experimental procedureBalb/c mice were subjected wet bedding for ...

metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. there are controversy aspects about its teratogenicity. a teratogenic agent can alter morphology or subsequent function of the fetus. the aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by metronidazole usin...

experimental  allergic encephalomyelitis (eae) is considered  as the murine model of multiple sclerosis. daidzein a phytostrogenic compound of soy is known to impose immunomodulatory and antioxidative effects. we conducted this study to assess the potential protective and therapeutic effects of daidzein on allergic encephalomyelitis. c57bl/6 mice  were induced  with  allergic encephalomyelitis ...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...