Psychological stress due to social isolation is known to cause abnormal feeding behaviors, but the influences of gender and aging on subchronic stress-induced changes in feeding behaviors are unknown. Thus, we examined the changes in body weight, food intake, and orexigenic ghrelin-related factors during 2 weeks of isolation stress in young and aged mice. Food intake increased significantly in ...

One of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. In this study the effect of the male hormone 5a-DHT on cytokine release by peritoneal macrophages (mΦ) of male and female NZB/BALBc mice was investigated. Macrophages from male mice activated with LPS produced a greater amount of IL-1β (21.8%) (p<0.05) and IL-...

Muscle fatigue is associated with a number of clinical diseases, including chronic pain conditions. Decreases in extracellular pH activates acid-sensing ion channel 3 (ASIC3), depolarizes muscle, protects against fatigue, and produces pain. We examined whether ASIC3-/- mice were more fatigable than ASIC3+/+ mice in a task-dependent manner. We developed two exercise protocols to measure exercise...

Source of Compounds. DMBA was supplied by EGA-Chemie, Steinheim, Germany, and l,2,3,4-dibenzanthracene (1,2,3,4DBA) by Nutritional Biochemicals Co., Cleveland, Ohio. The labeled compounds thymidine-3H and uridine-3H were purchased from the Radiochemical Centre, Amersham, En gland. The cocarcinogenic compound Al was prepared by Dr. H. Bresch, Heidelberg, Germany. Mice. Four-week-old inbred male ...

Objective- The objective of the present work was to investigate the effects of tramadol administration on sperm quality and testicular tissue in mice. Design- Experimental study Animal- Sixty-three mature male mice Procedures- Mice were randomly divided into three experimental groups (n=21) and the following treatments were intraperitoneally administered, 3 times a week, for 6 weeks: Control...