Immunisation experiments are performed on a large scale in laboratory animals e.g. for the production of antibodies. Depending on the immunisation protocol, severe discomfort may be induced. In several countries, guidelines for the immunisation of laboratory animals were drafted to refine immunisation protocols. One of the aspects that effects the immune response as well as the side effects is ...

Signet-ring cell change in thyroid adenoma is rarely reported [1–3]. We have recently seen such a tumour in a case of rheumatoid arthritis (RA) treated by methotrexate. Thyroid tumours are rarely reported in RA patients to our knowledge, mainly of carcinoma-type [4, 5]. The thyroid resection was performed for recent increase in size of a left thyroid nodule. At macroscopy, the nodule measured 1...

To the Editor: Phenol–croton oil formulas contained Septisol (SEP) (Steris, Mentor, OH), a discontinued antiseptic handwash that sodium C14-16 olefin sulfonate as surfactant.1da Silva Justo A. Lemes B.M. Nunes B. et al.Depth of injury Hetter's phenol-croton chemical peel formula using 2 different emulsifying agents.J Am Acad Dermatol. 2020; 82: 1544-1546Abstract Full Text PDF PubMed Scopus (2) ...