نتایج جستجو برای: lipodystrophy
تعداد نتایج: 5143 فیلتر نتایج به سال:
Localized loss of subcutaneous tissue can occur after panniculitis, injections of corticosteroids and other drugs, or associated with infectious, autoimmune or neurologic diseases. The "idiopathic lipoatrophies" are a group of poorly characterized diseases, with focal disappearance of subcutaneous fat, and usually the thighs, abdomen or the ankles are affected. Three subtypes have been describe...
OBJECTIVE Lipid accumulation in skeletal muscle and the liver is strongly implicated in the development of insulin resistance and type 2 diabetes, but the mechanisms underpinning fat accrual in these sites remain incompletely understood. Accumulating evidence of muscle mitochondrial dysfunction in insulin-resistant states has fuelled the notion that primary defects in mitochondrial fat oxidatio...
congenital generalized lipodystrophy (cgl) is a rare and progressive disorder (1 in 12 milion). common clinical manifestations are lipoatrophy, acromegaloid feature, acanthosis nigricans, hyperlipidemia, diabetes mellitus or abnormal glucose tolerance test.â rarely fatty liver and cirrhosis is seen. the highest number reported in literature is 8 cases from brazil and 6 cases from scandinavia, r...
Deletion mutation in BSCL2 gene underlies congenital generalized lipodystrophy in a Pakistani family
BACKGROUND Congenital generalized lipodystrophy (CGL) also known as Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a genetically heterogeneous disorder characterized by loss of adipose tissues, Acanthosis nigricans, diabetes mellitus, muscular hypertrophy, hepatomegaly and hypertriglyceridemia. There are four subclinical phenotypes of CGL (CGL1-4) and mutations in four genes AGPAT2, BSCL2...
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