نتایج جستجو برای: lipase gene

تعداد نتایج: 1154330  

Journal: :Journal of lipid research 2000
Y Friedlander P J Talmud K L Edwards S E Humphries M A Austin

Based on longitudinal twin data in women, we have previously demonstrated a genetic influence on changes in lipoprotein risk factors, blood pressure measurements, and body mass index over a decade. The present study examined the linkage between changes in lipoprotein variables and candidate genes encoding the hormone-sensitive lipase (HSL), hepatic lipase (HL), and lipoprotein lipase (LPL). The...

Samira Moradi Seyed Hadi Razavi, Seyed Mohammad Mousavi

The tremendous mounting interest in lipase production is pertinent to the biotechnological applications that these enzymes offer. Lipase, belonging to the hydrolyze enzymes, is involved in copious biological functions including: hydrolysis insoluble triacylglycerol to mono and diacylglycerols and glycerol. Submerge fermentation technique was applied for the efficient production of this. Briefly...

Journal: :Journal of Pure and Applied Microbiology 2022

Pseudomonas aeruginosa is an important pathogen that frequently associated with nosocomial infections. The goal of this work was to determine the relationship between quorum sensing system (QS) and production virulence factors in P. aeruginosa. A number 100 isolates were collected from various clinical sources different Mansoura university hospitals period April 2018 till 2019. PCR screening QS...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
R Guerra J Wang S M Grundy J C Cohen

Genetic factors strongly influence interindividual variation in plasma high density lipoprotein cholesterol (HDL-C) levels, but the specific genetic polymorphisms that confer heritable variation in HDL-C levels have not been identified. In this study we examined the relationship between polymorphism in LIPC, the gene encoding hepatic lipase, and plasma HDL-C concentrations using a sequential ap...

Journal: :The Journal of biological chemistry 1991
R A Anderson G N Sando

Molecular cloning of a full-length cDNA for human lysosomal acid lipase/cholesteryl ester hydrolase (EC 3.1.1.13) reveals that it is structurally related to previously described enteric acid lipases, but lacks significant homology with any characterized neutral lipases. The lysosomal enzyme catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Hong Wang Robert H Eckel

Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins, chylomicrons, and very low-density lipoproteins (VLDL). LPL-catalyzed reaction products, fatty acids, and monoacylglycer...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Robert A Hegele

Variant S447X To the Editor: Ross et al recently reported a dazzling series of in vivo experiments1 showing reversal of abnormal biochemical phenotypes in Lpl / mice through adenoviral-mediated gene transfer of the socalled “gain-of-function” S447X prematurely truncated human variant of lipoprotein lipase (LPL or LIPD). Furthermore, all readouts in lipase-deficient mice treated with this human ...

Journal: :Journal of lipid research 2004
Nengjun Yi Sally Chiu David B Allison Janis S Fisler Craig H Warden

BSB mice exhibit a wide range of obesity despite being produced by a backcross of lean C57BL/6J (B) x lean Mus spretus (SPRET/Pt) F1 animals x B. Previous linkage studies identified a quantitative trait locus (QTL) on mouse chromosome 7 with coincident peaks for hepatic lipase activity, obesity, and plasma cholesterol. However, these mice were not analyzed for gene x gene epistasis. Hepatic lip...

Lipases have many applications in biotechnology, thanks to their ability of acylglycerides hydrolysis. They alsp possess the unique feature of acting at the lipid-water interface, which distinguishes them from esterases. Commercially useful lipases are produced by microorganisms with the extracellular lipase being produced by many bacteria including Pseudomonas. The greatest production of lipas...

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