We have previously described the safety and immunomodulatory effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 in healthy volunteers. The scope of this work was to evaluate the effects of these probiotic strains on the hepatic steatosis of obese rats. We used the Zucker rat as a genetic model of obesity. Zucker-Lepr(fa/fa) ...

The regulatory mechanisms underlying the response to addictive drugs are complex, and increasing evidence indicates that there is a role for appetite-regulating pathways in substance abuse. Leptin, an important adipose hormone that regulates energy balance and appetite, exerts its physiological functions via leptin receptors. However, the role of leptin signaling in regulating the response to c...

Hematopoietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whether the niche is reciprocally regulated by HSCs. Here, we systematically assessed the expression and function of Angiopoietin-1 (Angpt1) in bone marrow. Angpt1 was not expressed by osteoblasts. Angpt1 was most highly expressed by HSCs, and at lower levels by c-kit(+) hematopoietic progeni...

Hypertension is responsible for high morbidity and mortality as one of the most important cardiometabolic risk factors. The aim of the study was to investigate whether the Gln223Arg in the leptin receptor (LEPR) influences the prevalence of hypertension. A cross-sectional study was carried out in individuals aged ≥ 18 years. Polymorphism identification was performed using PCR-RFLP analysis. Par...

OBJECTIVE To analyze the LEPR gene in obese children and to investigate the associations between molecular findings and anthropometric and metabolic features. SUBJECTS AND METHODS Thirty-two patients were evaluated regarding anthropometric characteristics, blood pressure, heart rate, serum glucose, insulin, leptin levels, and lipid profile. The molecular study consisted of the amplification a...

The effects of LEPR (rs709596309C > T) and FADS2 (rs321384923A G) single nucleotide polymorphisms on production quality attributes in purebred Duroc dry-cured hams were examined. As compared to LEPR-C– hams, the LEPR-TT had more intramuscular fat (+2.2% dry matter, P < 0.01). a result, they showed higher saturated (+1.54%, 0.01) lower polyunsaturated (?1.05%, fatty acids content brighter (L*: +...

Hypothalamic neuropeptides, neurotrophins, and systemic hormones modulate food intake and body composition. Although advances toward elucidating these interactions have been made, many aspects of the underlying mechanisms remain vague. Hypothalami from fat and lean chicken lines were assessed for differential expression of anabolic/orexigenic and catabolic/anorexigenic genes. Effects of triiodo...

3. NUNN, P. P. and McADANI, R. I'. W. J. Mycobacte-^5. rial infections and AIDS. Br. Med. Bull. 44 (1988) 801-803. 4. 01.ivAius, L. M., PizzARID.I.o, G. E. A., BENETUCCI,^6. J. and FARINA, M. 11. Lepromatous leprosy with II1V infection. Int. J. Lepr. 62 (1994) 295-296. VREEBURG, A. E. M. Clinical observations on leprosy patients with HIV-1 inlection in Zambia. Lepr. Rev. 63 (1992) 134-140. WoRi...

Genome-wide association studies (GWASs) have been used to search for susceptibility genes for type 2 diabetes and obesity in the Pima Indians, a population with a high prevalence of both diseases. In these studies, a variant (rs2025804) in the LEPR gene was nominally associated with BMI in 1,082 subjects (P = 0.03 adjusted for age, sex, birth year, and family membership). Therefore the LEPR and...