CONTEXT The genomic organization of the LEPR gene is complex and generates three independent transcripts whose respective functions are still poorly understood. METHODS/RESULTS We describe here a 7-year old patient with a homozygous 80 kb deletion in the chromosomal 1p31.3 region with early onset obesity, mental retardation and epilepsy. The deleted region comprises the proximal promoter and ...

Com o aumento significativo de casos obesidade em todo mundo, há também crescimento pesquisas para compreender suas causas. Sabido que os fatores predisponentes podem ser ambientais e/ou genéticos, estudo focou no gene do Receptor da Leptina (LEPR), sua ação na saciedade e a fisiopatologia quando presença polimorfismos, assim como interação destes com comorbidades estar diretamente relacionadas...

Trombley, S. 2014. Regulation of Leptin by Sexual Maturation and Energy Status in Male Atlantic Salmon (Salmo salar L.) Parr. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1151. 54 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8956-4. Leptin is a peripheral adiposity signal and a key hormone in energy balance regulation in mam...

Abstract Study question What are the characteristics of leptin receptor (LepR) expressing cells within endometrial mesenchymal stromal/stem (eMSCs) population? Summary answer LepR+ eMSCs display better stem-cell capacities as well distinctively quiescent properties compared to and LepR- eMSCs. is known already Single-cell RNA sequencing (scRNA-seq) reveals that cultured heterogeneous. LepR high...

Delhi: Century Publication; 2000. 2. Pandey A, Patel R, Uddin MJ. Leprosy control activities in India: integration into general health system. Lepr Rev 2006;77:210-8. 3. Rao VP, Bhuskade RA, Raju MS, Rao PV, Desikan KV. Initial experiences of implementation of functional integration (FI) in LEPRA India projects in Orissa. Lepr Rev 2002;73:167-76. 4. Leprosy Elimination Monitoring in India 2004 ...

Front Cover: The cover image is based on the Review Article LEP and LEPR are possibly a double-edged sword for wound healing by Kai-Wen Zhang et al., https://doi.org/10.1002/jcp.30936.

Investigation was conducted on 219 Jersey cows. LEPR genotypes were established with the PCRRFLP using the TaqI restriction endonuclease. The frequencies of the threonine encoding C allele and the methionine encoding T allele were 0.79 and 0.21, respectively. The across-families analysis did not revealed any significant effect of the LEPR T945M polymorphism on milk, fat and protein yields. The ...

Foot and ankle infections are the most common cause of hospitalization among diabetic patients, and Staphylococcus aureus is a major pathogen implicated in these infections. Patients with insulin-resistant (type 2) diabetes are more susceptible to bacterial infections than nondiabetic subjects, but the pathogenesis of these infections is poorly understood. C57BL/6J-Lepr/Lepr (hereafter, db/db) ...