Luminescent lanthanide complexes consisting of a lanthanide-binding chelate and organic-based antenna molecule have unusual emission properties, including millisecond excited state lifetimes and sharply spiked spectra, compared to standard organic fluorophores. We have previously used carbostyril (cs124, 7-amino-4-methyl-2(1H)-quinolinone) as an antenna molecule (Li and Selvin, J. Am. Chem. Soc...

Lanthanide salts have been studied for many years, primarily in Nuclear Magnetic Resonance (NMR) experiments of mixed lipid-protein systems and more recently to study lipid flip-flop in model membrane systems. It is well recognised that lanthanide salts can influence the behaviour of both lipid and protein systems, however a full molecular level description of lipid-lanthanide interactions is s...

Rational drug design depends on the knowledge of the three-dimensional (3D) structure of complexes between proteins and lead compounds of low molecular weight. A novel nuclear magnetic resonance (NMR) spectroscopy strategy based on the paramagnetic effects from lanthanide ions allows the rapid determination of the 3D structure of a small ligand molecule bound to its protein target in solution a...

Lanthanide-based luminescent ligand binding assays are superior to traditional radiolabel assays due to improving sensitivity and affordability in high-throughput screening while eliminating the use of radioactivity. Despite significant progress using lanthanide(III)-coordinated chelators such as diethylenetriaminepentaacetic acid (DTPA) derivatives, dissociation-enhanced lanthanide fluoroimmun...

Single-molecule magnets (SMMs) based on lanthanide ions display the largest known blocking temperatures and are the best candidates for molecular magnetic devices. Understanding their physical properties is a paramount task for the further development of the field. In particular, for the poly-nuclear variety of lanthanide SMMs, a proper understanding of the magnetic exchange interaction is cruc...

Four dinuclear lanthanide complexes [Gd2 (H2L)2 (µ-piv)2 (piv)2]·2CHCl3 (1), [Tb2 (H2L)2 (µ-piv)2 (piv)2]·2CHCl3 (2), [Dy2 (H2L)2 (µ-piv)2 (piv)2]·2CHCl3 (3) and [Eu2 (H2L)2 (µ-piv)2 (piv)2]·2CHCl3 (4) were synthesized by the reaction of appropriate Ln(III) chloride salts and a multidentate ligand, 2,2'-(2-hydroxy-3-methoxy-5-methylbenzylazanediyl)diethanol (H3L) in the presence of pivalic acid...

Lanthanide luminescence has wide applicability in both solid and solution state luminescence studies. The process of ligand sensitized luminescence has not only enhanced the lanthanide fluorescence but also found wider applicability in the field of immunoassay and drug delivery apart from probing the site of binding or complexation. The lanthanide fluorescence enhancement not only depends on th...

r-Process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the material after nuclear burning ceases, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. (2013, ApJ, 774, 25) and Tanaka & Hotokezaka...

Near-infrared (NIR) luminescent lanthanide complexes hold great promise for practical applications, as their optical properties have several complementary advantages over organic fluorophores and semiconductor nanoparticles. The fundamental challenge for lanthanide luminescence is their sensitization through suitable chromophores. The use of the metallacrown (MC) motif is an innovative strategy...

Detection of chelatable zinc (Zn(2+)) in biological studies has attracted much attention recently, because chelatable Zn(2+) plays important roles in many biological systems. Lanthanide complexes (Eu(3+), Tb(3+), etc.) have excellent spectroscopic properties for biological applications, such as long luminescence lifetimes of the order of milliseconds, a large Stoke's shift of >200 nm, and high ...