نتایج جستجو برای: intestinal drug delivery

تعداد نتایج: 868479  

M Hashemi Shabestari MN Sarbolouki

Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...

2017
Helong Liu Liangxing Tu Yongxin Zhou Zefang Dang Luting Wang Junfeng Du Jianfang Feng Kaili Hu

A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, -18.53 ± 1.65 mV in zeta potential and exhibited spherical morphology, with an encapsulation efficiency of 97.31 ± 0.60%. The system showed susta...

Journal: :Biomedical microdevices 2015
Line Hagner Nielsen Johan Nagstrup Sarah Gordon Stephan Sylvest Keller Jesper Østergaard Thomas Rades Anette Müllertz Anja Boisen

Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followe...

Background: Glibenclamide is a lipophilic drug widely used in type 2 diabetes treatment. However, its low bioavailability limits its use. Thus, novel formulations should be applied to improve the drug’s bioavailability. Objectives: This study aimed to develop alternative carriers for oral delivery of glibenclamide. For this purpose, two biocompatible polymers, poly(e-caprolactone) and poly(but...

Journal: :Advanced pharmaceutical bulletin 2011
Maryam Maghsoodi Elham Hemati Bahram Qadermazi Zahra Yari

PURPOSE A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period. METHODS Hollow microspheres were prepared by the emulsion solvent diffusion method usin...

Journal: :Journal of microbiology and biotechnology 2015
Hyun Jung Park Jiho Min Joo-Myung Ahn Sung-Jin Cho Ji-Young Ahn Yang-Hoon Kim

In this study, we developed lysosome-alginate beads for application as an oral drug delivery system (ODDS). The beads harboring lysosomes, which have antimicrobial activity, and various concentrations of alginate were characterized and optimized. For application as an ODDS, pH-dependent lysosome-alginate beads were generated, and the level of lysosome release was investigated by using antimicro...

2016
Stephen P. Woods Timothy G. Constandinou

This paper reports a novel medication release and delivery mechanism as part of a next generation wireless capsule endoscope (WCE) for targeted drug delivery. This subsystem occupies a volume of only 17.9mm3 for the purpose of delivering a 1 ml payload to a target site of interest in the small intestinal tract. An in-depth analysis of the method employed to release and deliver the medication is...

Journal: :Drug discovery today 2015
David J Brayden Sally-Ann Cryan Kenneth A Dawson Peter J O'Brien Jeremy C Simpson

High-content analysis (HCA) provides quantitative multiparametric cellular fluorescence data. From its origins in discovery toxicology, it is now addressing fundamental questions in drug delivery. Nanoparticles (NPs), polymers, and intestinal permeation enhancers are being harnessed in drug delivery systems to modulate plasma membrane properties and the intracellular environment. Identifying co...

Journal: :Energies 2022

Nano/microrobots (NMRs) are tiny devices that can convert energy into motion and operate at nano/microscales.54 Especially in biomedical research, NMRs have received much attention over the past twenty years because of their excellent capabilities great potential various applications, including on-demand drug delivery, gene cell transport, precise microsurgery. Reports published recent show syn...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2010
Fulden Buyukozturk James C Benneyan Rebecca L Carrier

Lipid based drug delivery systems, and in particular self-emulsifying drug delivery systems (SEDDS), show great potential for enhancing oral bioavailability but have not been broadly applied, largely due to lack of general formulation guidance. To help understand how formulation design influences physicochemical emulsion properties and associated function in the gastrointestinal environment, a ...

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