we studied the safety of a trivalent inactivated surface antigen (split virion, inactivated) influenza vaccine, begrivac® (novartis company), widely used in health care workers in kurdistan. a longitudinal follow-up study was performed in sanandaj city, west of iran, recruiting 936 people. a questionnaire was completed for each participant, and all symptoms or abnormal physical findings were re...

Objective(s): Th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. To address this point, the effect of nebulized inhalation of inactivated Mycobacterium phlei on modulation of asthmatic  airway  inflammation was investigated. Materials and Methods: 24 male BALB/c mice were randomly divided into three groups: control group (Group A), asthma model group (G...

A great number of researches over the last years are allocated to know cancer reasons, prevention and treatment strategies. Bacterial infections are one of the promoting factors in cancer development. The present study was carried out to study effects of heat-killed bacteria on cancer cell lines MCF7 and HT-29. To this purpose, four bacterial strains including Salmonella typhi, Sta...

Influenza directly or indirectly contributes to the four leading causes of global mortality, at rates that are highest in older adults. As the proportion of older adults in the Korean population is greater than in most other countries, influenza prevention is a greater public health priority in Korea than elsewhere. Conventional inactivated influenza vaccine (IIV) is less immunogenic and effica...

In the present study formaldehyde inactivated Montanide ISA70 based MG vaccine from the PCR confirmed positive local isolate was prepared and evaluated in broilers. An amount of immune gen per 0.3ml of the dose was 10 7 Colony forming units of the bacteria. At the age of 14 days, the broilers were randomly divided into three groups (A, B and C), each having twenty birds. Each bird of group A, B...

Main results 20 trials were included (14 RCTs) evaluating 3 types of vaccine: live attenuated aerosol (n=26 369), inactivated aerosol (n=1506), and inactivated parenteral (n=23 628). Live aerosol vaccines were not effective for preventing either type of clinically defined influenza (2 trials). Inactivated vaccines were effective in preventing influenza: both inactivated aerosol and inactivated ...

The first report of “virus” inactivation for vaccine purposes was described in 1886 when Daniel Elmer Salmon and Theobald Smith immunized pigeons with what they thought was a heat-killed hog cholera “virus” (Salmon and Smith 1886). Although in reality it was a cholera-like bacterium, it seeded the scientific community with evidence that immunization with inactivated pathogens can provide protec...

Influenza, whether seasonal or pandemic, causes substantial morbidity and mortality. Today, vaccines are the foundation of influenza prevention. Globally, influenza vaccine manufacturing capacity is at an all-time high [1], as are the number and types of influenza vaccines available on the market and in development. In the United States, in addition to the live attenuated and inactivated subuni...