This review summarizes recent progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD), with a focus on fibrosis. Several studies reported that CD4+ T cells cytotoxic activity promoted by secretion granzyme and perforin, (CD4+CTLs), disease-specific activated B cells, infiltrated inflamed tissues cooperated to induce tissue fibrosis autoimmune fibrotic diseases such as IgG4-...

Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by microangiopathy, immune dysregulation, and progressive fibrosis of the skin internal organs. Though not fully understood, pathogenesis SSc dominated microvascular injury, endothelial response that are thought to be associated with fibroblast activation related fibrogenesis. Among main clinical subsets, diffuse (dSSc)...

Contagious human coronavirus belong to family Coronaviridae and infects respiratory system causing the disease known as COVID-19 (WHO). To eradicate severe acute syndrome 2 pandemic, an effective vaccine should be developed. In current study immunoinformatics procedures were employed introduce a novel multi-epitope subunit vaccine. This can activate equally class I II leukocyte antigen antibody...