In the present study, we evaluated anti-Parkinson's activity of petroleum ether extract of Ficus religiosa (PEFRE) leaves in haloperidol and 6 hydroxydopamine (6-OHDA) induced experimental animal models. In this study, effects of Ficus religiosa (100, 200, and 400 mg/kg, p.o.) were studied using in vivo behavioral parameters like catalepsy, muscle rigidity, and locomotor activity and its effect...

Chronic dopamine replacement therapy in Parkinson's disease (PD) leads to deleterious motor sequelae known as L-DOPA-induced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [(±)propranolol], a nonselective β-adrenergic receptor (βAR) antagonist, may reduce LID. The present study used the rat unilat...

Cognitive deficits are often associated with motor symptoms in Parkinson's disease. This study investigates the ability of piribedil ([(methylenedioxy-3,4 benzyl)-4 pyperazinyl-1]-2 pyrimidine), a D(2)/D(3) dopamine (DA) receptor agonist with antagonist activity at alpha(2A)-adrenoceptors, to restore motor and attentional deficits in nigrostriatal 6-hydroxydopamine-lesioned rats. Subjects were ...

Chronic dopamine replacement therapy in Parkinson’s disease (PD) leads to deleterious motor sequelae known as L-DOPAinduced dyskinesia (LID). No known therapeutic can eliminate LID, but preliminary evidence suggests that dl-1-isopropylamino-3-(1-naphthyloxy)-2-propanol [( )propranolol], a nonselective -adrenergic receptor ( AR) antagonist, may reduce LID. The present study used the rat unilater...

A previous study from our laboratory revealed that moderate nigral dopaminergic degeneration caused emotional and cognitive deficits in rats, paralleling early signs of Parkinson's disease. Recent evidence suggests that the blockade of cannabinoid CB(1) receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease. Here, we investigated whether antagonism of CB(1) r...

Objective(s):Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. Materials and Methods: The effects of VBL treatment on motor, learning and memory functions of male and female Wistar rats were studied by behavioral related tests. Animals were given chro...

Cone-beam computed tomography (CBCT) is an important image modality for dental surgery planning, with high resolution images at a relative low radiation dose. In these scans the mandibular canal is hardly visible, this is a problem for implant surgery planning. We use anisotropic diffusion filtering to remove noise and enhance the mandibular canal in CBCT scans. For the diffusion tensor we use ...

objective(s)previous studies have shown that vitamin b as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including alzheimer’s and parkinson's diseases. the aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.materials and methodsanimals were randomly divi...

parkinson’s disease is one of the most common neurodegenerative disorders.  there are many documents about the effects of oxidative stress in parkinson’s disease etiology. angiotensin ii activates nadph dependent oxidases and causes superoxides formation.  peganum harmala l. extract, which has angiotensin converting enzyme (ace) inhibitory effect, is considered to evaluate oxidative stress inhi...

UNLABELLED The striatum is essential for many aspects of mammalian behavior, including motivation and movement, and is dysfunctional in motor disorders such as Parkinson's disease. The vesicular glutamate transporter 3 (VGLUT3) is expressed by striatal cholinergic interneurons (CINs) and is thus well positioned to regulate dopamine (DA) signaling and locomotor activity, a canonical measure of b...