Background: Oral squamous cell carcinoma (OSCC) is defined as an oral malignancy with worldwide prevalence of 90%. In 2018, the number cases observed 354.864 177.384 deaths globally. Early diagnosis for determining OSCC stage due to histopathological examination required sustain prognosis and minimize mortality. Determining mostly done manually highly dependent on skill experiences pathologist ...

Background: Crohn’s disease is an inflammatory bowel disease that can affect any part of the gastrointestinal (GI) tract including the mouth. Bowel symptoms are predominant. Oral involvement may precede the GI symptoms. This case report presents a patient affected by Crohn’s disease with oral onset. Case presentation: We present a 30-year-old pregnant woman complaining of chronic, ...

The use of high resolution, in vivo optical imaging may offer a clinically useful adjunct to standard histopathologic techniques. A pilot study was performed to investigate the diagnostic capabilities of optical coherence microscopy (OCM) to discriminate between normal and abnormal oral tissue. Our objective is to determine whether OCM, a technique combining the subcellular resolution of confoc...

p62/SQSTM1 (sequestosome1) has never been evaluated in oral epithelium. In order to clarify the role of p62/SQSTM1 in carcinogenesis in oral epithelium, both p62/SQSTM1 and Nrf2 were immunohistochemically evaluated in 54 carcinomas and 14 low grade dysplasias. p62/SQSTM1 knockdowns were also designed in oral cancer cells, and we analyzed the Nrf2 pathway, GSH contents and ROS accumulation. The ...

Introduction: Tobacco remains one of the most important preventable cause addiction, sickness and mortality in world as it affects oral epithelium. Normal epithelium undergoes continuous exfoliation or shedding its superficial cells, is replenished by new crop cells from basal layer. The rationale exfoliative cytology lies epithelial physiology. purpose this study to conduct quantitative cytomo...

BACKGROUND AND OBJECTIVE The junctional epithelium attaches to the enamel surface with hemidesmosomes (of which laminin-5 and integrin-alpha(6)beta(4) are the main components) in the internal basal lamina. Laminin-5 is also involved in cell motility with integrin-alpha(3)beta(1), although their functions have not yet been clarified.The purpose of this study was to determine the functions of tho...

Odontogenesis occurs because of a multi-stage complicated interaction between the oral epithelium and the mesenchymal tissue under the epithelium. Abnormal tissue interactions during this process can lead to ectopic tooth development (1). Ectopic tooth outside the oral cavity is rarely reported in the literature (1, 2) Ectopic teeth can be asymptomatic or can form odontogenic cysts, cause degra...

Amelo blastoma is a neoplasm that originates from odontogenic epithelium. It the second most common of oral cavity. Uni cystic ameloblastomas refer to those lesions show clinical, radio graphic, or gross features jaw cyst, but on histologic examination typical ameloblastomatous epithelium lining part cyst cavity, with without luminal and/ mural growth. Even though lesion not aggressive as solid...