BACKGROUND/AIMS Calprotectin is a 36.5 kD calcium and zinc binding protein in the S100 protein family. Fecal calprotectin levels are elevated in patients with inflammatory bowel disease and some other gastrointestinal disorders such as colorectal carcinoma. We decided to evaluate the fecal calprotectin level to see if it was able to distinguish between functional and organic causes of constipat...

BACKGROUND The evaluation of patients with abdominal discomfort is challenging and patient selection for endoscopy based on symptoms is not reliable. We evaluated the diagnostic value of fecal calprotectin in patients with abdominal discomfort. METHODS In an observational study, 575 consecutive patients with abdominal discomfort referred for endoscopy to the Department of Gastroenterology & H...

Introduction: Calprotectin, a member of the Ca2+-binding S100 family of proteins, makes up about 5% of the total protein content of the neutrophil. It is released upon activation and degranulation of neutrophils and correlates strongly with 111-indium-labeled leukocyte excretion. It was investigated as a promising tool in differentiating between Irritable Bowel Syndrome (IBS) and active Inflamm...

BACKGROUND Calprotectin in feces seems to be a more sensitive marker for gastrointestinal (GI) cancers than fecal occult blood, but its specificity may be too low for screening average risk populations. This study aims at evaluating the diagnostic value of fecal calprotectin as a screening biomarker for GI malignancies. MATERIALS AND METHODS In a case-control study, 100 patients with GI malig...

BACKGROUND European Panel on the Appropriateness of Gastrointestinal Endoscopy (EPAGE) criteria have been developed to increase diagnostic yield, but their predictive value is limited. We investigated the incremental diagnostic value of faecal calprotectin to EPAGE criteria. METHODS In a post-hoc analysis of a prospective study, EPAGE criteria were applied to 298 of 575 (51.8%) patients who h...

BACKGROUND The value of faecal biomarkers for screening small bowel inflammation in patients with Crohn's disease (CD) remains to be elucidated. This prospective study was to evaluate the utility of faecal biomarkers for detecting small intestinal inflammation. METHODS A total of 122 consecutive patients with a diagnosis of CD in the small intestine were screened for eligibility. Computed tom...

we conducted this study to compare fecal calprotectin between exclusively breastfed and formula or mixed fed infants aged one month and six months. sixty term infants were enrolled from the labor ward of valiasr hospital between oct 2011 and july 2015 and their fecal calprotectin was checked by the elisa method and hycult biotech kits. the enrolled infants had a birth weight of 2500-4000 g and ...