The effect of iron concentration during growth on the physicochemical surface properties of the colonial variants of Neisseria gonorrhoeae has been assessed by aqueous two-phase partitioning in a dextran-polyethyleneglycol system containing positively charged trimethylamino-polyethyleneglycol or hydrophobic polyethyleneglycol-palmitate. The complex effects of iron, in combination with other var...

Recombinant thrombopoietin has been reported to stimulate megakaryocytopoiesis and thrombopoiesis and it may be quite useful to treat patients with low platelet counts after chemotherapy. As little is known regarding the possible activation of platelets by thrombopoietin, we examined the effects of thrombopoietin on platelet aggregation induced by shear stress and various agonists in native pla...

OBJECTIVES Small diameter PTFE grafts are prone to thrombosis and intimal hyperplasia development. Heparin graft coating has beneficial effects but also potential drawbacks. The purpose of this study was to evaluate the experimental efficacy of PEG-hirudin/iloprost coated small caliber PTFE grafts. METHODS Thirty-six femoro-popliteal ePTFE grafts (expanded polytetrafluoroethylene, diameter 4 ...

e"> In order to study the effective factors on the quality and quantity of lecithin extracted from soybean oil and the residual amount of phosphatids in degummed oil, this study <span style="font-size:...

If six to seven days after copulation incisions are made under ether anesthesia into the uterus, and on the day following this operation one or several injections of hirudin are given, changes set in in the ovaries which correspond to those found at the time of ovulation; namely, a degeneration of all the follicles with the exception of the small ones. These degenerative changes are followed by...

OBJECTIVES This study aimed to explore platelet function tests relevant to the biological effects of clopidogrel that could help the clinical monitoring of drug efficacy. BACKGROUND Clopidogrel selectively inhibits the P2Y12 receptor, the major role of which is stabilization of aggregation, whereas initiation of aggregation depends on activity of both P2Y1 and P2Y12 receptors. METHODS Tests...

Three different mechanisms have been detected for the aggregation of platelets by tumor cells in a homologous human system based on inhibition studies with apyrase, hirudin, and phospholipase D. In the major group, platelet aggregation induced by the SKBR3 (adenocarcinoma), SKNMC (neuroblas toma), HT29 (adenocarcinoma), and HT144 (melanoma) cell lines was inhibited by apyrase and phospholipase ...

MUSTARD,, J .FRASER,DENNIS W .YERRY, RAELENE L. KINLOUGHRATHBONE, AND MARIAN A. PACKHAM. Factors resfonsible for ADPinduced release reaction of human platelets. Am. J. Physiol, 228(6) : 17571765. 1975,-Extensive aggregation of human platelets can be induced by ADP without secondary aggregation or release of granule contents. This occurs with washed platelets in Tyrode solution containing 0.35 Y...