نتایج جستجو برای: hippocampal ca1

تعداد نتایج: 46398  

Journal: :Neuropsychologia 2008
G Chételat M Fouquet G Kalpouzos I Denghien V De la Sayette F Viader F Mézenge B Landeau J C Baron F Eustache B Desgranges

The hippocampus is the brain structure of highest and earliest structural alteration in Alzheimer's disease (AD). New developments in neuroimaging methods recently made it possible to assess the respective involvement of the different hippocampal subfields by mapping atrophy on a 3D hippocampal surface view. In this longitudinal study on patients with mild cognitive impairment (MCI), we used su...

Journal: :NeuroImage 2010
Renaud La Joie Marine Fouquet Florence Mézenge Brigitte Landeau Nicolas Villain Katell Mevel Alice Pélerin Francis Eustache Béatrice Desgranges Gaël Chételat

Recent advances in neuroimaging have highlighted the interest to differentiate hippocampal subfields for cognitive neurosciences and more notably in assessing the effects of normal and pathological aging. The main goal of the present study is to investigate the effects of normal aging onto the volume of the different hippocampal subfields. For this purpose, we developed a new magnetic resonance...

Journal: :Neuroscience 2014
T Ikeno Z M Weil R J Nelson

Rapid remodeling of neurons provides the brain with flexibility to adjust to environmental fluctuations. In Siberian hamsters, hippocampal dendritic morphology fluctuates across the day. To reveal the regulatory mechanism of diurnal remodeling of hippocampal neurons, we investigated the effects of light signals applied under different photoperiodic conditions on dendritic morphology. A 4-h dark...

Journal: :Cerebral cortex 1999
K S Rockland G W Van Hoesen

Large sectors of polymodal cortex project to the hippocampal formation via convergent input to the entorhinal cortex. The present study reports an additional access route, whereby several cortical areas project directly to CA1. These are parietal areas 7a and 7b, area TF medial to the occipitotemporal sulcus (OTS), and a restricted area in the lateral bank of the OTS that may be part of ventrom...

Objective(s):The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp. Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: T...

Journal: :Journal of neurotrauma 2013
Haojie Mao Benjamin S Elkin Vinay V Genthikatti Barclay Morrison King H Yang

One interesting finding of controlled cortical impact (CCI) experiments is that the CA3 region of the hippocampus, which is positioned further from the impact than the CA1 region, is reported as being more injured. The current literature has suggested a positive correlation between brain tissue stretch and neuronal cell loss. However, it is counterintuitive to assume that CA3 is stretched more ...

Journal: :The Journal of Neuroscience 2016

Journal: :Learning & memory 2008
Michael VanElzakker Rebecca D Fevurly Tressa Breindel Robert L Spencer

If the hippocampus plays a role in the detection of novel environmental features, then novelty should be associated with altered hippocampal neural activity and perhaps also measures of neuroplasticity. We examined Fos protein expression within subregions of rat hippocampal formation as an indicator of recent increases in neuronal excitation and cellular processes that support neuroplasticity. ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Lingfei Hou Eric Klann

Hippocampal long-term depression (LTD) is a long-lasting decrease in synaptic strength that is most commonly studied at glutamatergic inputs to pyramidal cells in hippocampal area CA1. Activation of G-protein-coupled group I (including types 1 and 5) metabotropic glutamate receptors (mGluRs) by the pharmacological agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) elicits LTD in area CA1 of the hip...

Journal: :Stroke 2009
Kuniyasu Niizuma Hidenori Endo Chikako Nito D Jeannie Myer Pak H Chan

BACKGROUND AND PURPOSE p53-upregulated modulator of apoptosis (PUMA), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis. PUMA localizes to mitochondria and interacts with antiapoptotic Bcl-2 and Bcl-X(L) or proapoptotic Bax in response to death stimuli. Although studies have shown that PUMA is associated with pathomechanisms of cere...

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