PURPOSE Changes in concentrations of acute phase proteins in the serum of patients might be significant in the pathogenesis of Behçet disease. This report investigates the association between ocular disease activity and serum haptoglobin levels in patients with Behçet disease, and summarizes the current understanding of the correlation between acute phase proteins and Behçet disease based on bo...

THE FOLLOWING ANALYTES HAVE BEEN INVESTIGATED: urine albumin (u-albumin), plasma-transferrin (p-transferrin), p-haptoglobin, p-IgG, p-IgA, p-IgM, and p-orosomucoid. An unmodified commercial analytical system FIA Star (Tecator) with a two-channel injector (40 mul) was used. The prediluted plasma samples and antibodies are allowed to react for 33 s before the change in turbidity is measured as a ...

A macromolecular hemoglobin-binding protein, which was not detectable in normal bovine sera but appeared during acute phase inflammation, was purified, characterized, and designated as bovine haptoglobin (Hp). The purified protein had a molecular mass of 1,000-2,000 kDa, and was composed of two kinds of peptides, a 20-kDa peptide (alpha chain) and a 35-kDa glycopeptide (beta chain) linked by di...

Serum alpha(2)-macroglobulin levels were measured in normal subjects and in patients with various diseases by an immunochemical method. The values for normal men were 284 mg./100 ml. (+/-89.6 mg./100 ml.) and for normal women 350 mg./100 ml. (+/-94.5 mg./100 ml.). Men with rheumatoid arthritis had normal levels, but the levels in women were depressed. There was no relationship to the concentrat...

An attempt to determine the clinical significance of anti-Bga was performed by transfusing 51Crlabelled red blood cells (RBC) from HLA-B7 positive donors to four patients who had histories of anti-Bga. Pre-and post-transfusion samples showed no change in antibody titer scores, haptoglobin or complement levels. Three of the patients were then transfused with 51Cr-labelled RBC from HLA-B7 negativ...

Haptoglobin serves as an antioxidant by virtue of its ability to prevent hemoglobin-driven oxidative tissue damage. It was recently demonstrated that an allelic polymorphism in the haptoglobin gene is predictive of the risk for numerous microvascular and macrovascular diabetic complications. Because these complications are attributed in large part to an increase in oxidative stress, a study was...

1. Exercise-induced haemolysis has been implicated in the sub-optimal iron status of endurance-trained athletes. Accordingly, erythrocyte survival studies using 51Cr were performed on male and female distance runners (n = 20) and sedentary control subjects (n = 10) in order to determine whether the rate of erythrocyte destruction was altered as a consequence of repetitive exercise training. 2. ...

Because of the extreme impact of genome sequencing projects, protein sequences without accompanying experimental data now dominate public databases. Homology searches, by providing an opportunity to transfer functional information between related proteins, have become the de facto way to address this. Although a single, well annotated, close relationship will often facilitate sufficient annotat...

The effect of cortisol, dexamethasone, insulin and a liver cell growth promoting tripeptide on the secretion of plasma proteins into the medium of rat hepatocytes in monolayer cultures was studied. Cortisol and dexamethasone resulted in equal to or approximately 2.5-fold increase in the fibrinogen synthesis with general suppression of albumin and alpha-lipoprotein synthesis. On the other hand, ...

PURPOSE This study aimed to quantify the hemolytic responses of elite female football (soccer) players during a typical weekly training session. METHODS Ten elite female football players (7 field players [FPs] and 3 goalkeepers [GKs]) were recruited from the Australian National Women's Premier League and asked to provide a venous blood sample 30 min before and at the immediate conclusion of a...