The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...

273 The thrust in oral drug therapy of type 2 diabetes mellitus has been to make it safer (fewer adverse effects), convenient (once daily administration) and at the same time delay development of secondary failure to sulfonylureas. Sulfonylureas have been used for type 2 diabetes mellitus for over 50 years and are still the leading class of oral hypoglycemic agent. Concerns about cardiovascular...

Volume 86, Number 7 www.aafp.org/afp American Family Physician 669 A 39-year-old man presented with small nodules that had developed in his tattoos over the previous eight weeks. The nodules were not painful or pruritic. They were present only in the blue portions of the tattoo, but appeared in different tattoos on his arms and upper back (Figures 1 and 2). The tattoos were professionally appli...

HISTORY AND EXAMINATION — A 43-year-old man presented to his primary care physician for a “new patient evaluation.” Xerostomia, polydipsia, and polyuria, which had been attributed to chronic rhinosinusitis, were noted. A normal fasting blood glucose level had been recorded just before the onset of these symptoms, 5 years prior the visit. Physical examination and laboratory evaluation revealed t...

A six year-old female chinchilla was presented because of progressive weight loss. At the clinic, a yeast-stomatitis, a severely elevated glucose level and glucosuria were found. However, 10 days of diabetes mellitus therapy with glipizide did not halt weight loss. Evaluation of T4 level indicated the presence of hyperthyroidism. Treatment of the hyperthyroid state with locally applied thiamazo...