Abstract: iNOS is inducible by a variety of factors related to inflammation and referred to as inducible NOS(iNOS). It is regulated at the level of gene expression; once expressed, it produces NO at a high rate. iNOS gene-expression profiling is an important tool in understanding molecular markers of the responses of cells and tissues to external factors. In this article a semiquantitative reve...

Background:The zinc-finger X linked (ZFX) gene encodes a transcription factor that acts as a regulator of self-renewal of stem cells. Due to the role of ZFX in cell growth, understanding ZFX protein-protein interactions helps to clarify its proper biological functions in signaling pathways. The aim of this study is to define ZFX protein-protein interactions and the role of ZFX in cell growth. ...

the aim of this study was to analyze the polymorphisms existing in the 5´ flanking region, exonic, and some parts of the intronic regions as well as methylation analysis of the ednrb gene in cattle and goat. these regions were sequenced in three different breeds of cattle including sistani, golpayegani, and holstein and were compared with that of marghoz goat. the results identified that this g...

FET fusion proteins (FUS/EWS/TAF15) are critical in many human cancers, like sarcomas and leukemia. Interestingly, at the molecular level, they also form biomolecular condensates. However, underlying biophysical mechanism of these condensates on DNA remains poorly understood. Studies using single-molecule method, Curtains, demonstrated that finite sized droplets via liquid-liquid phase separati...

Background: Calotropis gigantea (family: Asclepiadaceae) has been known to contain cardiac glycosides. The C. gigantea extracts have been reported as cytotoxic to a few cancer cell lines. The present study was designed to examine the effect of Calotropis gigantea methanolic extract (CGME) on the growth and apoptosis in human breast carcinoma cell line (MCF-7 cells).Methods: The study was ...

Salinity is one of the most important abiotic stresses that decrease crop production. Transcription factors (TFs) are prominent regulators in plant responses to abiotic stress. In the present study, the expression pattern of four salt-induced genes encoding transcription factors, namely, MYB, RF2, GTF, and ARID was studied in response to salt stress (sodium chloride) and recovery conditions. Th...