A tannin, EA (1), and other nine non-tannins compounds, gallic acid (2), quercetin (3), myricetin (4), 3-O-methylellagic acid-4?-O-?-L-rhamnopyranoside (5), quercetin-3-O-?-D-galactopyranoside (6), kaempferol-3-O-?-D-glucoside (7), quercetin-3-O-?-D-glucuronide (8), quercetin-3-O-rutinoside (9), 3,3?,4-tri-O-methylellagic acid-4?-O-?-D-glucopyranosyl (10) were isolated from a valuable medicinal...

gastrointestinal (gi) diseases affect a large number of people all over the world. uncontrolled acid secretion and occurrence of gastric ulcers are common disorders of gi tract which pose serious problems to human health. many synthetic drugs have been used to treat gi disorders but a definite cure has not been discovered so far and the available medications cause several side effects. nigella ...

Immune mediators are involved in strain-specific manifestations of Helicobacter pylori infection, and the type of immune response is associated with production of PGE(2), which in turn influences gastric acid secretion. Acid secretion plays a pivotal role, not only in the pattern of H. pylori-induced gastritis and its consequences, but also in nonsteroidal anti-inflammatory drug (NSAID)-induced...

Indomethacin, nonsteroidal anti-inflammatory drug (NSAIDs), induced gastric damage and perforation through the excess generation of reactive oxygen species (ROS). Syzygium cumini (L.) Skeels is commonly used as a medicinal plant and is claimed to have antioxidant activities. The effects of Syzygium cumini (L.) Skeels aqueous extract (SCC) on antifree radical, anti-inflammation, and antiulcer of...

Gastric acid secretion is stimulated by all foods, especially proteins, and many beverages, the most potent beverages are milk and fermented substances such as beer and wine. The effects of food on mucosal integrity have been little studied, whereas non-steroidal anti-inflammatory drugs are well known to induce tissue injury.

The gastric mucosa is continuously exposed to many noxious factors and substances. How the gastric mucosa maintains structural integrity and resists auto-digestion by substances such as acid and pepsin puzzled clinicians and investigators for more than 200 years. The gastric epithelium must also resist damage from extrinsic agents, including Helicobacter pylori (H. pylori) and noxious ingestion...

Ethanolic extract of Tabernaemontana divaricata L. (TD) flowers were evaluated for analgesic and antiinflammatory effects on Wistar rat model. Analgesic and anti-inflammatory potential of TD flowers at doses of 125, 250 & 500 mg/kg was evaluated against the standard drug indomethacin at a dose of 20 mg/kg, p.o. Wistar rats of either sex of 6 numbers in each group was undertaken for study and ev...

Article history: Received on: 20/05/2014 Revised on: 18/06/2014 Accepted on: 07/07/2014 Available online: 27/09/2014 Aim of the study was to investigate Gastroprotective and anti-secretory effect of Pep-Up Tablet on pyloric ligation-induced gastric ulcer model in rats. Pep-Up Tablet is an Ayurvedic proprietary formulation which is manufactured and marketed by Vasu Healthcare Pvt. Ltd., Vadodara...

Effects of FRG-8701, a new histamine H2-receptor antagonist, on gastric acid secretion, necrotizing agents-induced gastric lesions and acute gastric or duodenal ulcer in rats were studied. In lumen-perfused rats, intravenous injection of FRG-8701 reduced gastric acid secretion, and its antisecretory effect was almost equipotent to that of famotidine but the duration of action was substantially ...