BACKGROUND Geriatric conditions may influence outcomes among patients receiving implantable cardioverter-defibrillators (ICDs). We sought to determine the prevalence of frailty and dementia among older adults receiving primary prevention ICDs and to determine the impact of multimorbidity on mortality within 1 year of ICD implantation. METHODS AND RESULTS The cohort included 83 792 Medicare pa...

OBJECTIVES To determine whether obesity is associated with the frailty phenotype and, if so, whether comorbid conditions or inflammatory markers explain this association. DESIGN Cross-sectional analysis of baseline data from the Women's Health and Aging Studies I (1992) and II (1994), complementary population-based studies. SETTING Twelve contiguous ZIP code areas in Baltimore, Maryland. ...

Many people with dementia have other complex health needs, including comorbidity and frailty. Most models of care focus on single diseases and do not take into account the needs of those with comorbidities and dementia. Integration, continuity of care and personalisation are particularly important for this vulnerable group. It is also important to recognise potential barriers to accessing care ...

BACKGROUND Frailty is an independent risk factor for cardiovascular outcomes. However, its trajectory after coronary artery disease treatment is unknown. METHODS AND RESULTS Three hundred seventy-four patients undergoing nonemergent cardiac catheterization followed by treatment (ie, 128 coronary artery bypass graft [CABG], 150 percutaneous coronary intervention [PCI], 96 medical therapy only)...

BACKGROUND Comprehensive Geriatric Assessment (CGA) is the gold standard to help oncologists select the best cancer treatment for their older patients. Some authors have suggested that the concept of frailty could be a more useful approach in this population. We investigated whether frailty markers are associated with treatment recommendations in an oncogeriatric clinic. METHODS This prospect...

Traditionally, frailty has been understood as a biological syndrome associated with bad health-related outcomes. However, nowadays there are no universally accepted diagnostic criteria for this syndrome, much less studies approaching it from a non-biological framework. Some previous work has been able to highlight social factors as important features implicated in the development of this entity...

We consider hazard (mortality) rates in heterogeneous populations consisting of ordered (in the defined stochastic sense) subpopulations. This setting can be interpreted via the fixed frailty models with one or more frailty parameters. The shape of the hazard rate is of main interest in this paper. Specifically, the deceleration and leveling off in the hazard rates (mortality plateaus) are disc...

It is assumed for the Cox’s proportional hazards model that the survival times of subjects are independent. This assumption might be violated in some situations, in which the collected data are correlated. The well-known Cox model is not valid in this situation because independence assumption among individuals is violated. For this purpose Cox’s proportional hazard model is extent to the analys...

BACKGROUND Despite the well-established power of frailty to predict mortality, and the known associations of socioeconomic status (SES) with mortality, it is largely unknown whether the linkage between frailty and mortality varies across different SES groups. This study aims to investigate whether SES moderates the association between frailty and mortality. METHODS We relied on the 2008/2009 ...