It has been previously reported that Wistar-Kyoto (WKY) rats may be useful in the study of the biological mechanisms involved in stress-related disorders. In the present study, WKY were treated acutely or chronically (one daily i.p. injection for 22-24 days) with the selective 5-HT reuptake inhibitor and clinically effective antidepressant and anxiolytic fluoxetine (5 and 20 mg/kg) and exposed ...

Agmatine has been recently emerged as a novel candidate to assist the conventional pharmacotherapy of depression. The acute restraint stress (ARS) is an unavoidable stress situation that may cause depressive-like behavior in rodents. In this study, we investigated the potential antidepressant-like effect of agmatine (10mg/kg, administered acutely by oral route) in the forced swimming test (FST)...

Early weaning (EW) has proven to be a factor that decreases the animal's organic resistance against adverse conditions. Climbing in the forced swimming test (FST) is the active behavior that expresses the will of the rat to escape the stressful situation. A possible association between these two stress factors (EW and FST) has not yet been reported as a plausible model for the study of stress a...

Post-partum depression (PPD) is a common mental disease in the perinatal period that profoundly affects mothers and their offspring. Some clinical studies have found that PPD is related to thyroid peroxidase antibodies (TPOAbs); however, the mechanism underlying this relationship is unclear. Female C57BL/6 mice immunized with adenovirus encoding the cDNA of the full-length mTPO (mTPO-Ad) were u...

Research on new compounds of therapeutic value for behavioral disorders has progressed recently. Several studies have reported neuropharmacological activities of plant derived terpenes. Farnesol is a sesquiterpene whose most popular source is fruits but the anxiolytic activity for farnesol is still unknown. The present study was conducted on 32 male Swiss Albino mice (8 in each group) to evalua...

Many biological activities have been reported in Fabaceae family. The aim of present study was to investigate antidepressant activities of Vicia faba hulhs extract. Antidepressant activities of methanolic extract was evaluated by modified forced swimming test (FST) and tail suspension tests (TST) in male Swiss albino mice. Extract showed significant antidepressant activities in both models. Ext...

Isomyristicin results from myristicin isomerization and is reported to have the same biological activity as myristicin, an antidepressant. Myristicin at a specific dose causes toxicity, so it necessary study isomyristicin, which estimated myristicin. However, there has been no test related isomyristicin having antidepressant activity. Therefore, this aimed determine optimum of decrease immobili...

Background: Depression is an important psychological disorder because it a common mental illness that leads to morbidity and suicide. Although appropriate antidepressant drugs exist, they usually have unpleasant side effects delayed onset. Objectives: Introducing new compounds such as medicinal plants oceanic living organisms alga appropriate. Here the depressive-like of Padina australis Hauck ...

In the present study, we investigated plasma corticosterone levels of genetically modified mice lacking noradrenaline transporter (NET(-/-)), in response to the forced swim test (FST) and tail suspension test (TST). FST strongly increased the plasma corticosterone level in the first minute after the test (significantly only in NET(+/+) mice), while TST was without any significant effect in both...

Impaired behavioral activation and effort-related motivational dysfunctions like fatigue anergia are debilitating treatment-resistant symptoms of depression. Depressed people show a bias towards the selection low effort activities. To determine if broadly used antidepressant fluoxetine can improve reverse dopamine (DA) depletion-induced anergia, male CD1 mice were evaluated for vigorous escape ...