نتایج جستجو برای: fluorouracil

تعداد نتایج: 15742  

Journal: :Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2020

Journal: :Letters in Drug Design & Discovery 2023

Background: Novel anti-tumor bioactivity compounds were designed by the strategy of modular hybridization with advantages 5-fluorouracil and dithiocarbamate derivatives. Methods: A series novel 5-fluorouracil-dithiocarbamate conjugates synthesized, characterized evaluated for their cytotoxic activities in vitro against B16, Hela U87MG MTT assay. Colony-formation, transwell migration, cell apopt...

Journal: : 2022

BACKGROUND: The therapeutic arsenal for the treatment of hypertrophic scars and keloids has expanded significantly in recent years. Traditional methods treatment, such as intraocular injection corticosteroids, pressure therapy cryotherapy, are increasingly supplemented with new methods. level evidence approaches increased due to development systematic reviews national international recommendati...

Journal: :Clinical science 1987
J R Bronk N Lister S Lynch

The transport of 5-fluorouracil, uracil and thymine has been studied with isolated jejunal loops of rat small intestine. High performance liquid chromatography was used to identify the pyrimidines and measure their concentrations. When the lumen of the intestine was perfused with 5-fluorouracil or uracil at 0.1 mmol/l or 0.2 mmol/l, the concentration in the serosal secretions was significantly ...

Journal: :Trends journal of sciences research 2022

Background: Cyclophosphamide (CPA) is a drug with wide spectrum of clinical uses. Its effectiveness in the treatment cancer (acute and chronic leukemias, lymphoma, multiple myeloma) non-malignant diseases such as rheumatoid arthritis vasculitis has been well established. Objectives: The present investigation aimed to study effect sub-lethal dose cyclophosphamide, 5-FU combination 5-FU, CPA on h...

امانی, مجتبی, عباسی, اسدالله, فکور, سینا, ماذنی, محمد, نجف زاده, نوروز, یلمه‌ها, یاسین,

Backgrounds and Objectives: All-trans retinoic acid (ATRA) which is a derivative of vitamin A, exert fundamental effects on regulation of cell growth, differenation and apoptosis. Recently, resistance to cisplatin and 5-fluorouracil developed in gastric adenocarcinoma and squamous cell carcinoma. In this study, we investigated the combination treatment of ATRA with cisplatin and 5-fluorouracil ...

2006
ALLAN R. GOLDBERG JOHN H. MACHLEDT ARTHUR B. PARDEE

The uptake and metabolism of radioactive uracil, uridine, phosphate, and 5-fluorouracil by the mouse L1210 leukemic leukocytes and a fluorouracil-resistant variant were investigated. The dual aims of the research were to locate a metabolic differ ence responsible for resistance, and to define the site of action of the inhibitor. The resistant cells possess a much less active "sal vage" pathway,...

Journal: :Cancer research 1966
A R Goldberg J H Machledt A B Pardee

The uptake and metabolism of radioactive uracil, uridine, phosphate, and 5-fluorouracil by the mouse L1210 leukemic leukocytes and a fluorouracil-resistant variant were investigated. The dual aims of the research were to locate a metabolic differ ence responsible for resistance, and to define the site of action of the inhibitor. The resistant cells possess a much less active "sal vage" pathway,...

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