Sclerosing Polycystic Adenosis (SPA) is a rare disease of the salivary glands, first described by Smith et al. in 1996, with histomorphological aspects similar to those from breast fibrocystic disorders1. Its pathogenesis is still unclear; however, it is considered a pseudo-neoplastic or reactive process. Recently, Skálová et al. showed clonality in six SPA cases. SPA affects mainly the parotid...

A diagnosis of fibrocystic disease of the pancreas is usually based on the following clinical criteria: failure to grow at the normal rate despite an adequate calorie intake, the passage of frequent loose, offensive stools often with a characteristic odour, and the tendency to respiratory tract infections which prove unusually resistant to treatment. These symptoms, together with a finding that...

BACKGROUND On the past decade a plethora of investigations were directed on identification of molecules involved in breast tumorogenesis, which could represent a powerful tool for monitoring, diagnostics and treatment of this disease. In current study we analyzed six previously identified medullary breast carcinoma autoantigens including LGALS3BP, RAD50, FAM50A, RBPJ, PABPC4, LRRFIP1 with cance...

Context: Breast an organ which is constantly under the influence of sex hormones, one frequent site neoplasm in human body. Benign breast diseases comprise a heterogeneous group lesions that present with varying symptoms or detected incidentally.Aims: To evaluate histopathological features benign and proliferative having potential to progress malignancy.Materials & Methods: All lumpectomy trucu...

OBJECTIVES To explore the separate and combined effects of work and family stress on menstrual disorders and fibrocystic changes in Chinese working women. METHODS Data were obtained from a cross-sectional study of 1,642 female railway workers. The Effort-Reward Imbalance Questionnaire and Family Stress Scale were used to measure work stress and family stress, respectively; the menstrual and b...

A consecutive series of 791 women who had attended diagnostic breast clinics during 1967-70 and been found to be free of malignant disease were later traced to determine their subsequent incidence of breast cancer. Of the 770 (97%) successfully traced, 22 had developed breast cancer. Based on data from the Welsh Cancer Registry only eight cases of breast cancer had been expected, so that the ex...

Two-color, multiparametric synthesis phase fraction (SPF) analysis of cytokeratin-labeled epithelial cells was flow cytometrically performed on both benign (SPFb) and malignant tissue samples (if available, SPFt) from 132 mastectomy/lumpectomy specimens. These data were then correlated with clinicopathologic features, including (1) tumor differentiation, (2) the proportion of tumor comprised of...