نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

2011
Eva Morales Mariona Bustamante Juan Ramon Gonzalez Monica Guxens Maties Torrent Michelle Mendez Raquel Garcia-Esteban Jordi Julvez Joan Forns Martine Vrijheid Carolina Molto-Puigmarti Carmen Lopez-Sabater Xavier Estivill Jordi Sunyer

INTRODUCTION Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL gen...

2016
Soo-In Sohn Young-Ju Oh Kyeong-Ryeol Lee Ho-Cheol Ko Hyun-Suk Cho Yeon-Hee Lee Ancheol Chang

A number of studies have been conducted on hybridization between transgenic Brassica napus and B. rapa or backcross of F1 hybrid to their parents. However, trait changes must be analyzed to evaluate hybrid sustainability in nature. In the present study, B. rapa and transgenic (BrAGL20) B. napus were hybridized to verify the early flowering phenomenon of F1 hybrids, and F1 hybrid traits were ana...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Ryo Saito Takashi Matsuzaka Tadayoshi Karasawa Motohiro Sekiya Nazuki Okada Masaki Igarashi Rie Matsumori Kiyoaki Ishii Yoshimi Nakagawa Hitoshi Iwasaki Kazuto Kobayashi Shigeru Yatoh Akimitsu Takahashi Hirohito Sone Hiroaki Suzuki Naoya Yahagi Nobuhiro Yamada Hitoshi Shimano

OBJECTIVE Elovl6, a long-chain fatty acid elongase, is a rate-limiting enzyme that elongates saturated and monounsaturated fatty acids and has been shown to be related to obesity-induced insulin resistance via modification of fatty acid composition. In this study, we investigated the roles of Elovl6 in foam cell formation in macrophages and atherosclerosis in mice. METHODS AND RESULTS To inve...

Journal: :Plant physiology 2007
Guy C Barker Tony R Larson Ian A Graham James R Lynn Graham J King

Natural genetic variation in fatty acid synthesis and modification pathways determine the composition of vegetable oils, which are major components of human diet and renewable products. Based on known pathways we combined diversity and genetic analysis of metabolites to infer the existence of enzymes encoded by distinct loci, and associated these with specific elongation steps or subpathways. A...

Journal: :jundishapur journal of microbiology 0
sara mohammadzadeh molecular biology department, pasteur institute of iran, tehran, ir iran farzin roohvand virology department, pasteur institute of iran, tehran, ir iran soheila ajdary immunology department, pasteur institute of iran, tehran, iran parastoo ehsani molecular biology department, pasteur institute of iran, tehran, ir iran; molecular biology department, pasteur institute of iran, p. o. box: 1316943551, tehran, ir iran. tel/fax: +98-2164112219, e-mail:; ali hatef salmanian, plant biotechnology department, national institute of genetic engineering and biotechnology, p. o. box: 14965-161, tehran, ir iran. tel: +98-2144580365, fax: +98-2144580395 ali hatef salmanian agricultural biotechnology department, national institute of genetic engineering and biotechnology, tehran, ir iran; molecular biology department, pasteur institute of iran, p. o. box: 1316943551, tehran, ir iran. tel/fax: +98-2164112219, e-mail:; ali hatef salmanian, plant biotechnology department, national institute of genetic engineering and biotechnology, p. o. box: 14965-161, tehran, ir iran. tel: +98-2144580365, fax: +98-2144580395

conclusions the canola oilseeds could provide a useful expression system to produce hcv core protein as a vaccine candidate. results western blot analysis using anti-his antibody confirmed the presence of a 15 kda protein in the seeds of t1 transgenic lines. the amount of antigenic protein accumulated in the seeds of these transgenic lines was up to 0.05% of the total soluble protein (tsp). mat...

Journal: :The Plant cell 2010
François Roudier Lionel Gissot Frédéric Beaudoin Richard Haslam Louise Michaelson Jessica Marion Diana Molino Amparo Lima Liên Bach Halima Morin Frédérique Tellier Jean-Christophe Palauqui Yannick Bellec Charlotte Renne Martine Miquel Marco Dacosta Julien Vignard Christine Rochat Jonathan E Markham Patrick Moreau Johnathan Napier Jean-Denis Faure

Very-long-chain fatty acids (VLCFAs) are essential for many aspects of plant development and necessary for the synthesis of seed storage triacylglycerols, epicuticular waxes, and sphingolipids. Identification of the acetyl-CoA carboxylase PASTICCINO3 and the 3-hydroxy acyl-CoA dehydratase PASTICCINO2 revealed that VLCFAs are important for cell proliferation and tissue patterning. Here, we show ...

Journal: :Journal of lipid research 1993
C L Marcelo W R Dunham

Adult human epidermal keratinocytes grow rapidly in medium that is essential fatty acid (EFA)-deficient. In this medium they exhibit decreased amounts of the fatty acids, 18:2, 20:3, 20:4, and contain increased amounts of monounsaturated fatty acids. [14C]- and [3H]acetate and radiolabeled fatty acids, 16:0, 18:2, and 20:4 were used to study the fatty acid metabolism of these cells. Label from ...

2017
Lamei Wang Bei Cai Shiwei Zhou Haijing Zhu Lei Qu Xiaolong Wang Yulin Chen

Myostatin (MSTN) is a powerful negative regulator of skeletal muscle mass in mammalian species that is primarily expressed in skeletal muscles, and mutations of its encoding gene can result in the double-muscling trait. In this study, the CRISPR/Cas9 technique was used to edit MSTN in Shaanbei Cashmere goats and generate knockout animals. RNA sequencing was used to determine and compare the tra...

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