نتایج جستجو برای: endocrine related cancer
تعداد نتایج: 2032507 فیلتر نتایج به سال:
We reviewed randomized phase II/III trials comparing first- or second-line endocrine therapy as monotherapy or in combination with targeted therapies for treatment of postmenopausal patients with hormone receptor-positive advanced breast cancer. First-line was defined as treatment for endocrine therapy-naïve advanced breast cancer or advanced disease treated with endocrine therapy in the adjuva...
There is concern that the addition of ovarian function suppression to endocrine treatment premenopausal patients with breast cancer will increase nonadherence in this population. Although oral therapy was fairly high first year study, it not worse when combined therapy.
Most men with breast cancer present with a mass in the breast, the evaluation of which should include a tissue diagnosis. If the presence of invasive cancer is established, adequate local therapy includes total removal of the breast. Most tumors are hormone-receptor positive. In high-risk patients, the use of endocrine adjuvant therapy and/or combined endocrine and chemotherapy should be consid...
We have used an immunoperoxidase technique utilizing a monoclonal antibody to the estradiol receptor to identify immunoreactive estradici receptor in breast carcinomas and have examined the relationship be tween the immunoreactive estradiol receptor and response to therapy in patients with advanced breast cancer. Fifty-six patients were found to be assessable for response to endocrine therapy. ...
We have used an immunoperoxidase technique utilizing a monoclonal antibody to the estradiol receptor to identify immunoreactive estradiol receptor in breast carcinomas and have examined the relationship between the immunoreactive estradiol receptor and response to therapy in patients with advanced breast cancer. Fifty-six patients were found to be assessable for response to endocrine therapy. T...
BACKGROUND The role of chemotherapy in addition to combined endocrine therapy for premenopausal women with endocrine-responsive early breast cancer remains an open question, yet trials designed to answer it have repeatedly failed to adequately accrue. The International Breast Cancer Study Group initiated two concurrent trials in this population: in Premenopausal Endocrine Responsive Chemotherap...
Tumor-adjacent normal (TAN) tissues, which constitute tumor microenvironment and are different from healthy provide critical information at molecular levels that can be used to differentiate aggressive tumors indolent tumors. In this study, we analyzed 52 TAN samples the Cancer Genome Atlas (TCGA) prostate cancer patients developed a 10-gene prognostic model accurately predict biochemical recur...
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