Estrogen has many positive effects on neural tissue in experimental model systems, including stimulation of neurite growth and neurotransmitter synthesis and protection against diverse types of neural injury. In humans, estrogen treatment is reputed to protect against Alzheimer's disease. To investigate potential mediators of estrogen's action and determine whether selective estrogen receptor m...

BACKGROUND Current treatment of chronic hepatitis C virus (HCV) infection has limited efficacy -especially among genotype 1 infected patients-, is costly, and involves severe side effects. Thus, predicting non-response is of major interest for both patient wellbeing and health care expense. At present, treatment cannot be individualized on the basis of any baseline predictor of response. We aim...

conclusions this study provided conserved b-cell epitopes and peptides that can be useful for designing entry inhibitors and vaccines able to cover a global population, especially where genotype 5a is common. results differences in the probability of glycosylation in e1 and e2 regions were observed in this study. three conserved antigenic b-cell epitopes were predicted in the e2 regions and als...

Abstract Ubiquitination is an important modification process in eukaryotic organisms, and ubiquitin ligase (E3) the most diversified component of this system. APIP6 (AvrPiz-t interacting protein 6) one E3s rice, involved recognition AvrPiz-t, effector from pathogen Magnaporthe oryzae , for initiation host defense against M. . However, structural detail how performs its function remains elusive....

The present paper introduces new classes of Stancu–Kantorovich operators constructed in the King sense. For these operators, we establish some convergence results, error estimations theorems and graphical properties approximation for considered, namely, that preserve test functions e0(x)=1 e1(x)=x, e2(x)=x2, as well e1(x)=x e2(x)=x2. class e2(x)=x2 is a genuine generalization introduced by Indr...

Genetic variation in lipid regulatory genes, particularly APOE, significantly influences the risk of coronary artery disease (CAD). This study aimed to assess the association between APOE polymorphism and angiographically assessed coronary stenosis in Pakistani population. A total of 695 subjects (22.3% female, mean age = 54 ± 11 years) presenting with chest pain were enrolled after obtaining w...

background: the uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. as such, uterine stem cells have been studied in recent years. transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. objective: the present research evaluated the mrna expression of oct4 and sox2 in the uterine tissues of ovariectomized mice tr...

Two novel dicationic binuclear Cu(I) complexes of the type [{(BPPP)E2)}Cu]2[BF4]2 (E = S (3a); Se (3b)) bearing (BPPP)E2 (BPPP bis(diphenyl phosphino)pyridine) pincer systems were isolated, and structurally characterized. The...