diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. it is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. it is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...

for prolonging the time that drug remains in stomach, new methods used as floating drug delivery systems, that available in various forms such as floating tablets. these systems enhance drug absorption and decrease plasma concentration fluctuations. iron deficiency and its inadequate absorption in diet are of community health problems. for prolonging the time that drug remains in stomach, new m...

background and objectives: there is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. cancer is no exception and studies focusing on evaluating the effects of different materials on dna, give valuable information in cancer researches and ca...

normal 0 false false false en-us x-none ar-sa approximately 1% of all pregnancies are in woman with epilepsy. although, the majority of children born to women with epilepsy are normal, they are at increased risk for malformations. notably, the teratogenicity of antiepileptic drugs is a well-defined subject. the incidence of major malformations in offspring of mothers with epilepsy who were trea...

Fuel efficiency has improved because of environmental policies and high gas prices. In most cases, increased vehicle usage is associated with negative outcomes because of potentially increasing emissions. In the New York City (NYC) taxi industry, however, increased vehicle usage corresponds to increased supply, which is meaningful because of limited the numbers of permissions and the fixed fare...

Clinical trials of intralymphatic immunotherapy (ILIT) have been performed to overcome the limitations of long-term therapy and the local or systemic hypersensitivity reactions in conventional allergen-specific immunotherapy, including subcutaneous or sublingual immunotherapy. Additionally, several animal studies of ILIT have been conducted in the form of translational or veterinary research. W...

OBJECTIVE A major preventable contributor to healthcare costs among older individuals is fall-related injury. We sought to validate a tool to stratify such risk based on readily available clinical data, including projected medication adverse effects, using state-wide medical claims data. DESIGN Sociodemographic and clinical features were drawn from health claims paid in the state of Massachus...

Gene-environment interactions contribute to complex disease development. The environmental contribution, in particular low-level and prevalent environmental exposures, may constitute much of the risk and contribute substantially to disease. Systematic risk evaluation of the majority of human chemical exposures, has not been conducted and is a goal of regulatory agencies in the U.S. and worldwid...

This paper examines the effects of “child-friendly” practices on learning in rural India. These are a set of pedagogical practices intended to improve education outcomes by increasing children’s inclusion in their learning environment. They are widely promoted in international development circles, and are an increasingly important plank of Indian education policy. This paper offers the first qu...

UNLABELLED Opioids are commonly used to treat patients with chronic pain (CP), though there is little evidence that they are effective for long term CP treatment. Previous studies reported strong associations between passage of medical cannabis laws and decrease in opioid overdose statewide. Our aim was to examine whether using medical cannabis for CP changed individual patterns of opioid use. ...