The internal dose experienced during a dermal exposure to soil-bound chemicals depends on many factors. An algorithm that describes the uptake of chemicals from soil as a function of exposure duration, exposure frequency, chemical concentration in the soil, soil loading, surface area, body weight, averaging time, and fractional absorption (ABS) is discussed in Chapter 6. The purpose of section ...

Purpose. The purpose of this study was to demonstrate the use of near-infrared (NIR) spectrometry for the in vitro quantification of econazole nitrate (EN) and estradiol (EST) in human skin. Methods. NIR spectra were collected from EN and EST powders to verify the presence of NIR chromophores. One percent EN cream, a saturated solution of EN, or 0.25% EST solution was applied to human skin. NIR...

OBJECTIVES The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory. METHODS Inhalation and dermal exposure loading were measured simultaneously in 70 subjects on multiple days resulting in 113 observations. Dermal exposure loading was assessed by ACC patches attached to likely...

BACKGROUND Literature data indicate that terrestrial life stages of amphibians may be more sensitive to xenobiotics than birds or mammals. It is hypothesized that dermal exposure could potentially be a significant route of exposure for amphibians, as there is evidence that their skin is more permeable than the skin of other vertebrate species. Thus, higher amounts of xenobiotics might enter sys...

objective(s): with the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (ag-nps). these nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. however, little attention has been paid to the toxicity of nanosilver wound dressing. this study was designed to investigate the ...

background we present a novel method for augmenting the standard c-v flap used for nipple reconstruction with a free dermal graft which aims to improve the appearance of the nipple reconstruction, decrease loss of projection and improve patient satisfaction overall. methods the surgical technique for performing a free dermal graft augmentation of a cv flap is described. all patients who underwe...

Dermal exposure to jet fuels has received increased attention with the recent release of newer fuels with novel performance additives. The purpose of these studies was to assess the percutaneous absorption and cutaneous disposition of topically applied (25 microl/5 cm(2)) neat Jet-A, JP-8, and JP-8(100) jet fuels by monitoring the absorptive flux of the marker components 14C naphthalene and (3)...