The aims of this retrospective study were to evaluate the efficacy of different steroid formulations (depot vs oral) and if the continuous administration of steroids throughout and beyond a CHOP protocol might improve the survival time and rate of cats with mediastinal lymphoma. The medical records of client-owned cats diagnosed with mediastinal lymphoma were reviewed at two veterinary referral...

The synthetic polypeptide depot-tetracosactrin (Synacthen-Depot) was given to nine steroid-treated asthmatic patients hypersensitive to animal corticotrophin. Eight had a satisfactory increase in plasma and urinary 17-hydroxycorticosteroids (17-OHCS). The remaining patient had been shown previously to have adrenal suppression. None of the patients developed allergic reactions to depot-tetracosa...

Multi-component, macromolecular complexes perform essential cellular functions that require spatial or temporal coordination of activities. Complexes also facilitate co-regulation of protein amounts and cellular localization of individual components. We propose a novel function of multi-component complexes as depots for regulatory proteins that, upon release, acquire new auxiliary functions. We...

This paper introduces an extension of the multi-start local search framework [1, 2, 3], named Systematic Diversification for the Vehicle Routing Problem with Time Windows, where the objective is to design least cost routes for a fleet of vehicles from one depot to a set of geographically scattered points. The routes must be designed in such a way that each point is visited only once by exactly ...

The design of a supply chain has been considered by many practitioners and researchers recently. One model that is used to optimize distribution from a single facility (depot) to a set of retailers over a given planning horizon and considering stock management decisions is known as Inventory Routing Problem (IRP). This model tries to optimize the trade-off between inventory and transportation c...