A 26-year-old man had been diagnosed with a cardiac murmur from birth. In 1998, he was admitted to hospital because of slight fatigue. A grade 5/6 continuous murmur was audible near the right sternal border at the second intercostal space. Doppler echocardiography detected an abnormal flow that suggested that an aneurysm of the right coronary sinus of Valsalva had ruptured into the right ventri...

The rates of washout of m X e and I-iodoantipyrine from the myocardium into the coronary sinus blood were determined over a wide range of hematocrits after simultaneous injection of the isotopes into the left anterior descending coronary artery of dogs. The ratio of the monoexponential disappearance constants (kx/k,), which is a measure of the ratio of the dynamic blood-tissue partition coeffic...

The article describes the features of venous blood outflow from heart in Baikal seal. objects for study were corrosion preparations 11 hearts seal aged 1 month to 10 years. In our research we used methods preparation, filling vessels with use "Kudo" mounting foam, photographing and sketching branching vessels. It was established that seal, occurs through prominent coronary sinus large, intermed...

Recently, total chemical synthesis of thromboxane was achieved. The in vitro activity of synthetic thromboxane A2 is indistinguishable from biologically generated material. The present study describes the in vivo characterization of synthetic thromboxane A2 on the regional blood flow distribution of the canine heart. Local injections of synthetic thromboxane A2 into the coronary vasculature cau...

OBJECTIVES Although the signalling pathways of late preconditioning have been extensively investigated, its consequence for myocardial metabolism remains unknown. Thus, myocardial oxygen consumption (MVO2) was evaluated before and under late preconditioning. METHODS In 7 chronically instrumented dogs, we measured MVO2 in vivo at baseline and during inotropic stimulation with dobutamine (10 an...

BACKGROUND Because of higher life expectancy, the number of elderly patients today with degenerative aortic diseases is on the increase. Often artificial aortic roots are needed to replace the native tissue. This surgical procedure requires re-implantation of the previous separated coronary arteries into the wall of the prosthesis. Regardless of the prosthesis type, changes in the reinsertion t...

Ten patients with chronic effort angina and coronary artery disease (luminal diameter reduction greater than 75%) were stressed by atrial pacing (140 beats/minutes) before and 15 minutes after intravenous propranolol (mean dose 7.4 mg). Myocardial substrate exchange of oxygen, blood lactate, plasma free fatty acids, citrate, glucose, glutamate, and alanine as well as coronary sinus blood flow w...

As an approach to delivery of inert gas to the myocardium in the presence of coronary artery obstruction, Kr in saline was injected into a catheter in the coronary venous system of intact anesthetized dogs. Isotope delivered at the level of the great cardiac vein was selectively localized in the region of myocardium subserved by the vein and the left anterior descending artery. Similarly, injec...

Setty, Srinath, Wei Sun, Rodolfo Martinez, H. Fred Downey, and Johnathan D. Tune. -Adrenoceptor-mediated coronary vasoconstriction is augmented during exercise in experimental diabetes mellitus. J Appl Physiol 97: 431–438, 2004. First published February 20, 2004; 10.1152/japplphysiol.01122.2003.—This study tested whether -adrenoceptor-mediated coronary vasoconstriction is augmented during exerc...

Changes in intramyocardial tissue pressure modulate the relationship between coronary pressure and flow during the cardiac cycle. The present study compared the relation between measured and calculated diastolic subendocardial tissue pressure and coronary pressure at zero flow in anesthetized dogs after modulation of either coronary sinus (i.e. Fogarty catheter) or left ventricular intracavity ...