Purpose The purpose of this study was to investigate the contribution of mast cells to early neutrophil recruitment during ocular inflammation. Methods In a murine model of corneal injury, the epithelium and anterior stroma were removed using a handheld motor brush. Cromolyn sodium (2% in PBS) eye drops were administered topically for mast cell inhibition. In vitro, bone marrow-derived mast c...

BACKGROUND Angiogenin (ANG), a component of tears, is involved in the innate immune system and is related with inflammatory disease. We investigated whether ANG has an immune modulatory function in human corneal fibroblasts (HCFs). METHODS HCFs were cultured from excised corneal tissues. The gene or protein expression levels of interleukin (IL)-1beta (β), IL-4, IL-6, IL-8, IL-10, complements,...

PURPOSE The gene expression profile of human corneal endothelium (CE) was established with the gene signature system. A novel gene, GS3582, was abundantly transcribed in the CE compared with other tissues according to a human gene expression database. This protein was designated corneal endothelium-specific protein (CESP)-1. The tissue distribution and subcellular localization of CESP-1 was ass...

In our previous studies, we noted a non-uniform distribution of protein tracer preferentially entering the anterior stromal lamellae of the cornea from the limbus. Given other differences reported previously between the anterior and posterior lamellae of the cornea, and the number of corneal disorders in which abnormalities are preferentially confined to either the anterior or posterior lamella...

purpose: to evaluate the correlation between corneal power and corneal horizontal white to white diameter in myopic patients scheduled for lasik surgery. methods: overall, in 840 eyes of 420 myopic subjects scheduled for lasik, horizontal white to white diameter and mean corneal power were obtained using orbscan ii. pearson correlation test and regression analysis were used to detect any correl...

purpose : to evaluate the effects of topical sesame oil in the treatment of severe corneal alkali injury in rabbits methods : in a double-blind experiment, 30 healthy white rabbits were randomized into a sesame oil treatment group (n=15) and a control group (n=15). under general anesthesia, severe corneal alkali injuries were induced by application of 1 n sodium hydroxide for 40 seconds to the ...

purpose: to present two patients with acute corneal hydrops, superimposed with infectious keratitis using topical steroids. patients and findings: the first case was a 44-year-old man with acute corneal hydrops in his left eye which was on topical steroids for one week. visual acuity was hand motion at presentation and there was a large epithelial defect with stromal infiltration and corneal ed...

PURPOSE Invasion of bacteria into the corneal stroma induces the infiltration of leukocytes and subsequent corneal ulceration. The role of corneal fibroblasts in the detection of bacterial invasion into the stroma was investigated by examining the in vitro expression of the receptor complex for lipopolysaccharide (LPS), a common component of Gram-negative bacteria, as well as the possible effec...