background respiratory failure is one of the most important related factors to morbidity and high mortality in neonates with congenital diaphragmatic hernia (cdh). determining indices that could ultimately and perceively predict the disease severity, prognosis and morbidity of these neonates is crucial. objectives this study aimed to evaluate the predictive value of pao2/fio2 ratio (p/f ratio) ...

Objective Fetal endoscopic tracheal occlusion (FETO) has been reported to be beneficial to patients with congenital diaphragmatic hernia (CDH). It needs highly invasive procedures for balloon removal (fetoscopic and/or ultrasound-guided), and carries a given risk for both mother and fetus. We have reported the potential usefulness of high-intensity focused ultrasound (HIFU) as a noninvasive ext...

BackgroundMinimal invasive surgery (MIS) is increasingly used for the correction of congenital diaphragmatic hernia (CDH) and esophageal atresia (EA). It important to master these complex procedures, preferably preclinically, avoid complications. The aim this study was validate recently developed models train MIS procedures preclinically.MethodsTwo low cost, reproducible (one CDH one EA) were v...

Congenital diaphragmatic hernia is known to be associated with esophageal atresia, which is a rare association. We report a rare occurrence of congenital diaphragmatic hernia and lower esophageal atresia.

Congenital diaphragmatic hernia (CDH) is a serious medical condition in which the developing diaphragm forms incompletely, leaving a hole through which the abdominal contents can enter the thoracic space and interfere with lung growth. A perturbation of the retinoid system has been linked to the etiology of CDH. This includes findings that nitrofen, which induces CDH in rodents, inhibits the ke...

BACKGROUND/PURPOSE The molecular pathophysiology of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains poorly understood. The Wnt signaling pathway and downstream targets, such as bone morphogenetic proteins (BMP) 4 and other factors such as late gestation lung protein 1 (LGL1), are essential to normal lung development. Nitrofen-induced hypoplastic CDH rodent lungs demonstrate dow...

background the most common space occupying lesions of the fetal thorax are congenital diaphragmatic hernia (cdh), congenital cystic adenomatoid malformation (ccam), and bronchopulmonary sequestration (bps). although applications of prenatal mri have been vastly improved in the recent years, its use in the assessment of space occupying lesions of the fetal chest differs among centers. objectives...

Few studies have examined ventilatory modes exclusively in infants born at term. Synchronous intermittent mandatory ventilation (SIMV) compared to intermittent mandatory ventilation (IMV) is associated with a shorter duration of ventilation. The limited data on pressure support, volume targeted ventilation and neurally adjusted ventilatory assist demonstrate only short term benefits in term bor...

Congenital diaphragmatic hernia (CDH) may be isolated or associated with other structural anomalies, the latter with poor prognosis. The defect allows viscera to herniate through the defect into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients....