Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeu...

Nanoparticle Drug Delivery The encapsulation of nanoparticles in hydroxypropyl methyl cellulose is key to treat colorectal cancer through oral administration. In article 2202672 by Ilaria Rea, Hélder A. Santos, and co-workers, gelatin-coated diatomite loaded with galunisertib are functionalized an anti-L1-CAM antibody that targets metastatic colon cells. These then encapsulated a gastro-resista...

BACKGROUND Megachannel is a newly developed colonic access system allowing rapid and multiple passes of the colonoscope to the right side of the colon. OBJECTIVE The aim of this study was to evaluate the safety and clinical feasibility of placing a 100 cm Megachannel prototype in the right side of the colon. SETTING Six centers, international, both surgeons and gastroenterologists performin...

Ulcerative colitis (UC) is a type of inflammatory bowel disease with high recurrence rate. In this regard, sulfasalazine and immunosuppressive medications are often used for an extended period in clinical practice, but their effectiveness limited, they prone to side effects. Modern research has shown that herbal active ingredients Traditional Chinese Medicine (TCM), such as polyphenols, alkaloi...

Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation, it is classified as a type of inflammatory bowel disease. The microspheres carrier for the delivery of the dosage form to the colon is composed of physiological and biodegradable natural polysaccharides and which in turn cause low systemic toxicity,...

If one excludes those cases of perforation which are secondary to volvulus, intestinal atresia, congenital bands, intussusception, herniation of the bowel, meconium ileus or Hirschsprung's disease, there remains a group of newborn infants who develop perforation of the colon without apparent cause. Spontaneous perforation of the colon in the neonate was first described by Breslau in 1863. It is...

PURPOSE Adjuvant chemotherapy is one of the significant treatments for colon cancer in clinic. However, it does not achieve the desired therapeutic efficacy, largely due to chemotherapeutic resistance. Integrinβ6 (ITGB6) is expressed in malignant colonic epithelia, but not in normal epithelia, and is associated with the progression, metastasis, and chemotherapeutic resistance of colon cancer. A...

PURPOSE This study aimed to develop an efficient and safe strategy to introduce suicide genes into colon cancer cells. EXPERIMENTAL DESIGN In this study, we fused an enhanced carcinoembryonic antigen promoter (CEA) to a suicide gene, cytosine deaminase (CD). This construct was delivered into colon cancer cells using calcium phosphate nanoparticles (CPNP). The cells were then treated with the ...

background: colorectal cancer is a common and lethal disease with various distribution of incidence in different part of the world and it is known as the third most common cause of cancer death in the world. since several studies in the world represented different survival rates for colorectal cancer in this study we aimed to determine the survival of a group of iranian patients and some relate...

Span 80 (sorbitan monooleate) vesicles behaved differently from conventional phospholipid vesicles (liposomes) because the former had a more fluid interface. After doxorubicin hydrochloride (DOX) was encapsulated into the Span 80 vesicle (loading efficiency: 63 %), DOX-loaded Span 80 vesicles (DVs) were thereafter added to Colon 26 cells. It was suggested, from the flow cytometric analysis and ...