introduction: behcet's disease is a chronic disease with multisystem involvement characterized clinically by oral and genital aphthae, cutaneous lesions and ophthalmologic, neurologic and gastrointestinal manifestation. nervous system involvement occurs in 5.3 – 30% of patients, mostly in brain stem and basal ganglia. the common manifestations are pyramidal signs, central nervous plegia, p...

Central nervous system (CNS) cancers are the second most frequent malignancy (and the most common solid tumor) in childhood. In recent years, significant advances in surgery, radiotherapy, and chemotherapy have improved survival in children with these tumors. However, a significant proportion of patients with CNS tumors suffer progressive disease despite such treatment. Advances in the understa...

Central nervous system (CNS) hemangioblastoma is the most common manifestation of von Hippel-Lindau (VHL) disease. It is found in 70-80% of VHL patients. Hemangioblastoma is a rare form of benign vascular tumor of the CNS, accounting for 2.0% of CNS tumors. It can occur sporadically or as a familial syndrome. CNS hemangioblastomas are typically located in the posterior fossa and the spinal cord...

ependymomas accounts for about 2%–6% of cns and 60%–70% of spinal cord tumors. several histological patterns of these neoplasms are well known, but little attention has been devoted to a variant composed of giant cells. in spite of apparently “worrisome” histology, giant cell ependymoma seems to be a neoplasm with a relatively good prognosis. this report presents a case of giant cell ependymoma...

A STRIKING, characteristic, electrocardiographic pattern associated with central nervous system (CNS) lesions, particularly subarachnoid hemorrhage, has been described.1-3 The combination of prolonged Q-T interval and large upright or deeply inverted T waves was originally described in association with cerebrovascular accidents and has come to be recognized as the typical CNS electrocardiogram....

BACKGROUND Central nervous system (CNS) tumors are the most common cause of cancer-related death in children. Little is known about the demographics and treatment of pediatric brain tumors in low- and middle-income countries (LMICs). METHODS We performed a retrospective chart review of all pediatric patients who presented to the neurosurgical service at Tribhuvan University Teaching Hospital ...

CNS Primitive Neuroectodermal tumors (CNS-PNETs) are members of the embryonal family of malignant childhood brain tumors, which remain refractory to current therapeutic treatments. Current paradigm of brain tumorigenesis implicates brain tumor-initiating cells (BTIC) in the onset of tumorigenesis and tumor maintenance. However, despite their significance, there is currently no comprehensive cha...

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Solitary fibrous tumors (SFTs) most commonly occur in the pleura, but may also occur in the...

The immune-to-brain communication is still in its infancy but there is a great deal of data to suggest its importance in several central nervous system (CNS) disorders. There are three cytokines, interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha (TNFα), which have emerged to have a major role in the CNS and in different CNS disorders. The majority of the published work to date has been...

The patient succumbed to CNS disease 3 months afterward, despite CNS-directed chemotherapy. Sequencing of the BCR-ABL kinase domain from BM blasts, at the time of BC, and CSF tumor cells, at CNS relapse, did not show any mutation. The lack of BM blastosis, the reduced marrow BCR-ABL levels and the absence of a mutated clone, in BM and CSF, at the onset of meningeal leukemia, indicate that syste...