Disruption of the murine mdr2 gene leads to the complete absence of biliary phospholipids. We tested the hypothesis that the increase in biliary phospholipid output induced by fibrates is mediated via induction of the hepatic mdr2 gene and its encoded product, the P-glucoprotein canalicular flippase. Increased levels of mdr2 mRNA were observed in the liver of mice treated with different fibrate...

44 A suckling piglet model was used to study nutritional and pharmacologic means of 46 stimulating hepatic fatty acid β-oxidation. Newborn pigs were fed milk diets containing either longor medium-chain triglycerides (MCT). The long-chain control diet was 48 supplemented further with clofibric acid (0.5%) or isoproterenol (40 ppm), and growth was monitored for 10 to 12 d. Clofibrate increased ra...

Objective: To study the effect of sodium sulfadimethylpyrimidine (SDMP) on different forms of CYP 450 enzymes induced by phenobarbital (CYP 2B1, 2B2 and 3A), isoniazid (CYP 2E1), benzo(a)pyrene (CYP 1A1), clotrimazole (CYP 3A), and clofibrate (CYP 4A). Materials and Methods: Chickens (Hubbard, male) weighing 250–300 g were divided into 17 groups of six each. Five experimental sets were prepared...

Rats were maintained on a riboflavin-deficient diet or on a diet containing clofibrate (0.5%, w/w). The activities of the mitochondrial FAD-dependent straight-chain acyl-CoA dehydrogenases (butyryl-CoA, octanoyl-CoA and palmitoyl-CoA) and the branched-chain acyl-CoA dehydrogenases (isovaleryl-CoA and isobutyryl-CoA) involved in the degradation of branched-chain acyl-CoA esters derived from bran...

Each gold atom in the binuclear title compound, [Au(2)(C(9)H(9)N(2)O(3)S)(2)(C(25)H(22)P(2))], is coordinated within an S,P-donor set that defines a slightly distorted linear geometry [S-Au-P angles = 172.77 (6) and 173.84 (6)°], with the distortion due in part to a close intra-molecular Au⋯O contact [2.968 (11) and 2.963 (4) Å]. The mol-ecule adopts a U-shaped conformation allowing for the for...

In a double-blind prospective trial clofibrate was found not to influence significantly the clinical and laboratory indices thought to reflect the state of fat embolism in patients with fractures.

Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is recognized as a metabolic liver disease in the world. The purpose of this study was to investigate the preventive effects of Punica granatum extract on fatty liver disease in the rats receiving high fat diet. Material and Methods: In this study rats were divided into 6 groups: healthy control, feeding with high fat diet, feeding ...