Migraine and its transformation to chronic migraine are healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression (SD), as a means to develop novel therapeutic targets for episodic and chronic migraine. SD is the likely cause of migraine aura and migraine pain. It ...

Migraine and migraine variants are common, chronic and incapacitating neurovascular disorders with a high impact on health resources. There is an extensive evidence base provided by double-blind, placebo-controlled trials showing that topiramate is a safe, effective and well tolerated drug in the management of migraine and its variants, being especially promising in the management of migraine-v...

Obesity is an epidemic problem seen in many people with and without migraine. How are obesity and migraine linked, and what are the risk factors for migraineurs battling the bulge? First, a definition of obesity is needed. Typically, obesity is defined as a body mass index (BMI) of 30 or more. BMI calculators are available online or as apps on smart phones, but if calculation is desired, this i...

66 CLINICAL MANIFESTATIONS AND EPIDEMIOLOGY Migraine headache is a chronic, debilitating disorder characterized by severe head pain that is usually unilateral and throbbing in nature (1). If left untreated, a migraine can persist for up to 72 hours (2). It is frequently associated with nausea (87%) and/or vomiting (56%), and other symptoms such as photophobia and phonophobia are also quite comm...

PURPOSE To identify consistent results of voxel-based morphometry (VBM) studies in migraine. METHODS Whole-brain VBM studies comparing migraine patients with healthy controls (HC) were systematically searched in PubMed, ISI Web of Science, Embase, and Medline databases from January 1990 to Dec 2014. Coordinates were extracted from clusters with significant difference in gray matter volume (GM...