Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes synthesised to detect ChEs but they not detected changes in ChE distribution associated with AD pathology. Probes are typically screened using spectrophotometric methods pure enzyme specificity and kinetics. However, the biochemical properties of pathology altered. The pres...

The measurement of the plasma activities of glutamic-oxaloacetic and glutamic-pyruvic transaminases, aldolase, cholinesterase, and isocitric, lactic, and phosphogluconic dehydrogenases in random samples of blood was found to be of no value in the differential diagnosis of hepatitis, obstructive jaundice, hepatic cirrhosis, and neoplastic conditions involving the liver. Serial determinations of ...

Loss of cognition is one of the age related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer's. Crataeva nurvala Buch-Ham, a well explored traditional Indian medicinal plant of Westernghats, is routinely used as folkloric medicine to treat various ailments in particular urolithiasis and neurological disorders associated with cognitive dysfunction. The o...

00 Diethyl 0 -p -nitrophenyl thiophosphate (I), generally known as parathion or E 605, is an insecticide which is of value against a variety of crop pests. Its mammalian toxicity is usually ascribed to its power of inhibiting cholinesterase, and this is also possibly its mechanism of insecticidal action. The in vitro inhibition of the enzyme was first studied by DuBois, Doull, Salerno & Coon (1...

1. Marked differences in the duration of symptoms were observed when sublethal single doses of different dimethyl phosphate esters were injected intravenously into rats. The compounds inducing prolonged symptoms (OO-dimethyl S-ethylthioethyl phosphorothiolate, OO-dimethyl S-ethylsulphinylethyl phosphorothiolate and OO-dimethyl S-ethylsulphonylethyl phosphorothiolate) either persisted themselves...

DNA of 3 unrelated individuals carrying the human plasma butyrylcholinesterase C5 variant (CHE2) was isolated from white blood cells. Southern blot patterns of DNA restriction fragments probed with each of the 4 butyrylcholinesterase exons provided evidence that the production of C5 is not directed by a second butyrylcholinesterase gene. This finding supports the suggestion that the C5 variant ...

Di-isopropylfluorophosphonate (D.F.P.) has the property of inhibiting the enzyme cholinesterase, and it has been recommended for use in the treatment of glaucoma, paralytic ileus, and myasthenia gravis. It is manufactured on a laboratory scale as this is sufficient to produce the quantities required for clinical use. The circumstances in which two chemical workers were intoxicated with D.F.P. a...

OBJECTIVE To determine whether (i) cholinesterase activity is increased in the saliva of patients with primary Sjogren's syndrome (pSS), (ii) increased levels of cholinesterase of lymphocyte origin could interfere with the secretory activity of submandibular acinar cells, and (iii) hydroxychloroquine at therapeutic doses could interfere with cholinesterase activity. METHODS The Ellman method ...

Background: Alzheimer's disease (AD) is the most common brain disorder and remains a major health concern worldwide. Considering highly complex mechanisms of AD, search for agents based on multitarget-directed ligands (MTDLs) strategy to treat AD may be more promising than traditional “one drug-one target” strategy. Inhibition Poly (ADP-ribose) polymerases-1 (PARP-1) has potentially therapeutic...