Retinal pigment epithelium (RPE)-choroid-sclera preparations from black dutch-belted rabbits were sealed in an Ussing chamber maintained at 37-39 degrees C. Typical preparations produced a spontaneous voltage (Ve) of 12.5 mV (retina side positive) and possessed an electrical resistance (R) of 350 ohm-cm2. Both of these values can be attributed to the RPE. Ouabain and amiloride diminished the Ve...

The development of paraventricular porencephalic diverticula following ventriculography (Fig. 1 and 2) has been described in children suffering from moderate hydrocephalus (Lorber and Grainger, 1963; Grainger and Lorber, 1963; Lorber and Emery, 1964). The present case illustrates such a lesion existing in an apparently normal child some years after ventriculography. It further illustrates that ...

In 1944 Hamman and Rich described an acute form of diffuse interstitial pulmonary fibrosis in four patients who died within six months of the onset of symptoms. Many cases with a similar syndrome have since been reported. The majority of these, however, have run a more chronic course and the outcome has not always been fatal. The disorder has been fully reviewed by Rubin and Lubliner (1957) and...

THE occurrence of ulcers in the small intestine during the course of treatment of patients with thiazide diuretics together with enteric-coated tablets of potassium chloride or enteric-coated tablets of combinations of thiazides and potassium chloride has suggested to several investigators that some factor in these medications may be responsible for the genesis of such ulcers.1' 2 As a matter o...

APERIA, ANITA C., C. G. OVE BROBERGER, AND &GRID SEDERLUND. Relationship between renal artery perfusion pressure and tubular sodium reabsorption. Am. J. Physiol. 220(5): 1205-1212. 1971.In the in situ perfused dog kidney perfusion pressure was gradually increased from 110 to 325 mm Hg. Renal blood flow remained stable until perfusion pressure exceeded 225-240 mm Hg, the glomerular filtration ra...

Beckwith-Wiedemann syndrome (BWS) is caused by dysregulation of imprinted genes on chromosome 11.p15.5. The syndrome includes overgrowth, macroglossia, organomegaly, abdominal wall defects, hypoglycemia, and long-term malignancy risk. No patient who has BWS has been reported with hypopituitarism. We describe a patient who presented at birth with macrosomia, macroglossia, respiratory distress, j...

C HLOROTHIAZIDE and other diuretics of similar structure have become established as valuable therapeutic agents in the control of hypertension. While not entirely free of toxicity, these drugs produce few disturbing side-effects. In addition, they have a relatively flat dose response curve in the therapeutic range. This permits fairly uniform dose schedules, which is an important feature of dru...

The kidney consistently releases ammonia into the renal venous circulation of normal subjects and patients with compensated liver disease (1-4). Under conditions of normal acid-base balance, the quantity released usually approximates the amount of ammonia excreted into urine (3, 4). From determinations of arteriovenous ammonia differences across various organs, it has become apparent that the r...

In this study, a second case of hyperinsulinemic hypoglycemia due to activation of glucokinase is reported. The 14-year-old proband had a history of neonatal hypoglycemia, treated with diazoxide. He was admitted with coma and convulsions due to nonketotic hypoglycemia. His BMI was 34 kg/m(2), and his fasting blood glucose ranged from 2.1 to 2.7 mmol/l, associated with inappropriately high serum...

1. Distal blockade by simultaneous administration of ethacrynic acid and chlorothiazide was performed in healthy subjects whose extracellular fluid was expanded by iso-osmotic sodium chloride or bicarbonate. The results obtained were compared with those from non-expanded subjects (Ardaillou & Fillastre, 1969). 2. By this technique urine approximates in composition to proximal tubular fluid and ...