A27-year-oldwomanpresentedwithgeneralizeddystonia thatbeganatage 15yearsasdystonicposturingof the righthandwhenwriting. Shewas diagnosedwith cervical dystonia and botulinum toxin injections were tried, providing minimal pain relief and no improvement of thedystonia. The cervical dystonia was partially responsive to sensory tricks (Video, A). Shewasmost bothered by her cervical dystonia, and dis...

BACKGROUND Deep brain stimulation (DBS) of the globus pallidus internus (GPi) is an effective and well-tolerated treatment for idiopathic generalized dystonia. More recently, it has been applied as a treatment for focal and segmental dystonias. This patient population offers an opportunity to study the effects of alteration of pallidal outflow on previously normal limb function. METHODS We so...

A 77-year-old Japanese woman with cervical dystonia was admitted to our institution for steroid therapy acute hepatitis secondary autoimmune hepatitis. We prescribed oral bisphosphonates prevent steroid-induced osteoporosis. Six days after the first dose of bisphosphonate, patient complained pharyngeal and back pain. Upper gastrointestinal endoscopy revealed an ulcer in esophagus (Figure A). Co...

Dystonia is a neurological disorder characterized by intermittent or sustained muscle contractions that cause abnormal, usually repetitive, movements and postures. Dystonic movements can be tremulous and twisting and often follow a pattern. They are frequently associated with overflow muscle activation and may be triggered or worsened by voluntary action. Most voluntary muscles can be affected ...

To investigate the clinical features of early-onset primary torsion dystonia (EO-PTD), 57 consecutive genetically characterized patients with onset before 21 years were studied. Sex, ethnic origin, family history of dystonia, age at onset, disease duration, site of dystonia onset and distribution at latest examination, dystonia progression, time to generalization, and motor disability were note...

Rapid onset dystonia-parkinsonism (RDP) is a rare movement disorder with autosomal dominant inheritance, characterised by sudden onset of dystonic spasms and slowness of movement. To date, three families have been described that share linkage to the same location on chromosome 19q13, designated DYT12. Very recently, mutations in the ATP1A3 gene at the DYT12 locus have been demonstrated in seven...

BACKGROUND There is limited information on the phenomenology, clinical characteristics and pathophysiology of alleviating manoeuvres (AM), also called 'sensory tricks' in cervical dystonia (CD). METHODS Individual data, collected from 10 sites participating in the Dystonia Coalition (http://clinicaltrials.gov/show/NCT01373424), included description of localisation and phenomenology of AM coll...

Though multiple medical and psychiatric causes of torticollis have been described, cervical dystonias resulting from distant somatic dysfunctions have not. This article describes the treatment of a 62-year-old woman in whom refractory retrotorticollis of surmised pelvic etiology developed after a fall. Structurally, cervical dystonias have been addressed as problems that originate in the head a...