The influence of various factors along the processing-loading pathway in limiting the diversity of HLA-B27-bound peptides around a core protein sequence was analyzed. The C5 proteasome subunit-derived RRFFPYYV and RRFFPYYVY peptides are natural B*2705 ligands. The octamer is an allospecific CTL epitope. Digestion of a 27-mer fragment of C5 revealed that both ligands are generated from this prec...

Components of innate immunity have recently been implicated in the regulation of developmental processes. Most strikingly, complement factors appear to be involved in limb regeneration in certain urodele species. Prompted by these observations and anticipating a conserved role of complement in mammalian regeneration, we have now investigated the involvement of complement component C5 in liver r...

1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one (2) was isolated from Curcuma domestica as a curcumin (1)-related compound, which we named C5-curcumin. Intrigued by the potent antitumor activity of C5-curcumin (2)-related 1,5-bisaryl-1,4-pentadiene-3-ones [bis(arylmethylidene)acetones, termed C5-curcuminoids], we previously conducted a structure-activity relationship study of C5-curcumi...

Co–Fe–Al catalysts prepared using coprecipitation at laboratory scale were investigated and extended to pilot for high-calorific synthetic natural gas. The with different metal loadings analyzed BET, XRD, H2-TPR, FT-IR. An increase in the loading of showed low spinel phase ratio, leading an improvement reducibility. Among catalysts, 40CFAl catalyst afforded highest C2–C4 hydrocarbon time yield,...

A novel series of pyrazole derivatives containing imidazo[1,2-a]pyridine D1-D8 moiety has been synthesized. The reaction 2-aminopyridine with 4-phenylphenacyl bromide and 4-bromophenacyl gave the products A1, respectively. These then reacted DMF POCl3 to obtain new aldehyde B B1. two aldehydes were condensed various acetophenone substitutes yield corresponding chalcone C1-C10. Following this, c...

OBJECTIVE Measurement of plasma C2 glucose enrichment is cumbersome. Therefore, the plasma C5 glucose-to-(2)H(2)O rather than the plasma C5-to-C2 glucose ratio commonly has been used to measure gluconeogenesis and glycogenolysis during hyperinsulinemic-euglycemic clamps. The validity of this approach is unknown. RESEARCH DESIGN AND METHODS Ten nondiabetic and 10 diabetic subjects ingested (2)...

BACKGROUND It has been reported that C5 palsy is a potential complication of both anterior and posterior cervical spine surgery, although several mechanisms of C5 palsy following posterior cervical surgery have been proposed, few reports about correlative risk factors have been elaborated on C5 palsy after anterior cervical decompression and fusion (ACDF). OBJECTIVE The purpose of this study ...

The conversion of biomass into chemicals, fuels and energy using the bio-refinery concept has attracted lot of attention. In particular, lignocellulosic biomass, consisting of cellulose (ca. 50%), hemicellulose (ca. 30%) and lignin (ca. 20%) is of special interest because it is non-edible and in plentiful supply. Hemicellulose is a heterogeneous polymer, made up of C5 and C6 sugars (such as xyl...