1,11-Epoxysteroids may be obtained by an intramolecular remote functionalization using Suarez reagent (diacetoxyiodobenzene/I(2)) and irradiation with visible light. We have found that photolysis with visible light may be advantageously replaced by microwave irradiation to prepare 1,11-oxygen bridges resulting in higher yields and shorter reaction times especially in the case of sensitive subst...

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A decision maker tests whether the gradient of loss function evaluated at a judgmental is zero. If test does not reject, action decision. rejects, sets equal to boundary rejection region. This statistical rule admissible and conditions on sample realization. The confidence level reflects maker’s aversion uncertainty. applied problem asset allocation. JEL Classification: C1, C11, C12, C13, D81

We reviewed the literature regarding the effects of conjugated linoleic acid (CLA) preparations enriched in specific isomers, cis9, trans11-CLA (c9, t11-CLA) or trans10, cis12-CLA (t10, c12-CLA), on tumorigenesis in vivo and growth of tumor cell lines in vitro. We also examined the potential mechanisms by which CLA isomers may alter the incidence of cancer. We found no published reports that ex...

BACKGROUND AND PURPOSE Phosphorylation of δ opioid receptors (DOP receptors) by cyclin-dependent kinase 5 (CDK5) was shown to regulate the trafficking of this receptor. Therefore, we aimed to determine the role of CDK5 in regulating DOP receptors in rats treated with morphine or with complete Freund's adjuvant (CFA). As μ (MOP) and DOP receptors are known to be co-regulated, we also sought to d...

Formation of the C11-C1' bond through application of Barton's radical decarboxylation and quinone addition is the cornerstone of a new convergent and concise synthesis of the marine metabolites avarol (1) and avarone (2; see scheme), for which antimitotic, antileukemic, and antiviral effects have been reported.

For the development of novel hepatoprotective agents, C11, C28, C2,3,23 or C2,23,28 functional groups on asiatic acid were modified, and their hepatoprotective effects were evaluated. Most of the prepared compounds displayed potent hepatoprotective activities against CCl4and galactosamine (GaIN)-induced hepatotoxicity. Especially, compounds 16 and 20 showed the most significant hepatoprotective...

Jing Zhang†, Jie Tang†], Cong Ma†, Hanghang Tong‡, Yu Jing†, and Juanzi Li† †Department of Computer Science and Technology, Tsinghua University Tsinghua National Laboratory for Information Science and Technology (TNList) ‡School of Computing, Informatics, and Decision Systems Engineering, ASU {zhangjing12, ma-c11}@mails.tsinghua.edu.cn, {jietang, yujing5b5d,lijuanzi}@tsinghua.edu.cn, hanghang.t...