Previous findings indicate that administration of abeta-adrenoceptor antagonist systemically blocks glucocorticoid impairment of memory retrieval. Here, we report that beta-adrenoceptor activation in the hippocampus and the basolateral complex of the amygdala (BLA) is implicated in the impairing effects of glucocorticoids on memory retrieval. The specific glucocorticoid receptor (GR) agonist 11...

Proteoglycans are associated with the initiation of atherosclerosis due to their binding of apolipoproteins on lipid particles leading to retention in the vessel wall. The signaling pathways through which growth factors regulate the synthesis and structure of proteoglycans are potential therapeutic targets. Platelet-derived growth factor (PDGF) is present in atherosclerotic plaques and activate...

Previous studies have indicated that stress-activated glucocorticoid hormones induce temporary memory retrieval impairment. The present study examined whether adrenal steroid receptors in the hippocampus mediate such glucocorticoid effects on spatial memory retrieval. The specific glucocorticoid receptor (GR) agonist 11beta, 17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU...

The contextual interference (CI) effect is a robust phenomenon in the (motor) skill learning literature. However, CI has yielded mixed results in complex task learning. The current study addressed whether the CI effect is generalizable to bimanual skill learning, with a focus on the temporal evolution of memory processes. In contrast to previous studies, an extensive training schedule, distribu...

The replicative polymerases cannot accommodate distortions to the native DNA sequence such as modifications (lesions) to the native template bases from exposure to reactive metabolites and environmental mutagens. Consequently, DNA synthesis on an afflicted template abruptly stops upon encountering these lesions, but the replication fork progresses onward, exposing long stretches of the damaged ...

contextual interference is one of the instructional methods for several skills.the aim of this research was to determine the effects of interference beforeperformance and interference during performance on the acquisition and retentionof generalized motor program and parameter in basketball skills with an emphasison the examination of contextual interference hypotheses and self-regulationlearni...

OBJECTIVES To investigate mortality in men admitted to hospital with acute urinary retention and to report on the effects of comorbidity on mortality. DESIGN Analysis of the hospital episode statistics database linked to the mortality database of the Office for National Statistics. SETTING NHS hospital trusts in England, 1998-2005. PARTICIPANTS All men aged over 45 who were admitted to NH...

Boolean satisfiability (SAT) and its extensions are becoming a core technology for the analysis of systems. The SAT-based approach divides into three steps: encoding, preprocessing, and search. It is often argued that by encoding arbitrary Boolean formulas in conjunctive normal form (CNF), structural properties of the original problem are not reflected in the CNF. This should result in the fact...

In theory and practice of modern SAT solving, clause-elimination procedures are essential for simplifying formulas in conjunctive normal form (CNF). Such procedures identify redundant clauses and faithfully remove them, either before solving in a preprocessing phase or during solving, resulting in a considerable speed up of the SAT solver. A wide number of effective clause-elimination procedure...